Neuropeptide Y interaction with the adrenergic transmission line: a study of its effect on alpha-2 adrenergic receptors

Maria Martire, G. Pistritto

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

13 Citazioni (Scopus)

Abstract

Neuropeptide Y (NPY), first isolated in 1982, is widely distributed among the neurons of the central and peripheral nervous systems, often in close association with catecholamines. Because of its wide distribution and concentrations in selected areas of the brain, NPY is considered a putative neurotransmitter with several possible physiological effects including modulation of blood pressure, food intake and pituitary hormone release at a central level. Peripherally, the peptide seems to be involved, via direct and indirect mechanisms, in noradrenaline (NA)-mediated vasoconstriction. The ability of NPY to interact with the catecholamine transmission line may underly a possible modulatory influence of NPY on catecholamine receptor characteristics. We recently observed interaction between alpha-2 adrenergic receptors and those for NPY at the presynaptic level. Additional data from our studies in spontaneously hypertensive rats suggest that impairment of these interactions may contribute to the hypertension in this strain.
Lingua originaleEnglish
pagine (da-a)203-215
Numero di pagine13
RivistaPharmacological Research
Volume25
Stato di pubblicazionePubblicato - 1992

Keywords

  • Animals
  • Brain
  • Humans
  • Neurons
  • Neuropeptide Y
  • Norepinephrine
  • Rats
  • Receptors, Adrenergic, alpha
  • Receptors, Neuropeptide Y
  • Receptors, Neurotransmitter
  • Synaptic Transmission

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