Neuropeptide Y enhances the inhibitory effects of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat

Maria Martire, Paolo Preziosi, K Fuxe, G Pistritto, Lf Agnati

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of the alpha 2-adrenergic agonist clonidine (0.1 microM) on potassium (15 mM K+) induced 3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. The effect of NPY was detectable at low concentrations (1 nM) and was not dose-dependent. Neuropeptide Y alone produced no significant effects on 3H-NA release. The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynaptic alpha 2-adrenoreceptor function to inhibit 3H-NA release.
Lingua originaleEnglish
pagine (da-a)113-124
Numero di pagine12
RivistaJournal of Neural Transmission
Volume67
Stato di pubblicazionePubblicato - 1986

Keywords

  • Animals
  • Clonidine
  • Male
  • Medulla Oblongata
  • Neuropeptide Y
  • Norepinephrine
  • Potassium
  • Rats
  • Rats, Inbred Strains
  • Synaptosomes

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