Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation

Sk Kritas; A Saggini; A Caraffa; P Antinolfi; A Pantalone; S Frydas; M Rosati; M Tei; A Speziali; R Saggini; Franco Pandolfi; P. Conti

Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation

Sk Kritas^*, A Saggini, A Caraffa, P Antinolfi, A Pantalone, S Frydas, M Rosati, M Tei, A Speziali, R Saggini, Franco Pandolfi, P. Conti

^*Autore corrispondente per questo lavoro

Gabriele d'Annunzio University

Risultato della ricerca: Contributo in rivista › Articolo

16 Citazioni (Scopus)

Abstract

Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

Lingua originale	Inglese
pagine (da-a)	177-181
Numero di pagine	5
Rivista	Journal of Biological Regulators and Homeostatic Agents
Volume	28
Numero di pubblicazione	2
Stato di pubblicazione	Pubblicato - 2014
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Endocrinologia, Diabete e Metabolismo
Immunologia e Allergia
Fisiologia
Immunologia
Oncologia
Endocrinologia
Fisiologia (medica)
Ricerca sul Cancro

Keywords

Animals
Autoimmune Diseases
Humans
IgE
Inflammation
Mast Cells
Nerve Growth Factor
Receptors

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AU - Kritas, Sk

AU - Saggini, A

AU - Caraffa, A

AU - Antinolfi, P

AU - Pantalone, A

AU - Frydas, S

AU - Rosati, M

AU - Tei, M

AU - Speziali, A

AU - Saggini, R

AU - Pandolfi, Franco

AU - Conti, P.

PY - 2014

Y1 - 2014

N2 - Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

AB - Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

KW - Animals

KW - Autoimmune Diseases

KW - Humans

KW - IgE

KW - Inflammation

KW - Mast Cells

KW - Nerve Growth Factor

KW - Receptors

KW - Animals

KW - Autoimmune Diseases

KW - Humans

KW - IgE

KW - Inflammation

KW - Mast Cells

KW - Nerve Growth Factor

KW - Receptors

UR - https://publicatt.unicatt.it/handle/10807/60940

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VL - 28

SP - 177

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JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

IS - 2

ER -

Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Altri file e collegamenti

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