Neurofilament light chain as a biomarker in neurological disorders

Paolo Calabresi, Mario Di Filippo, Lorenzo Gaetani, Kaj Blennow, Massimiliano Di Filippo, Lucilla Parnetti, Henrik Zetterberg

Risultato della ricerca: Contributo in rivistaArticolo in rivista

130 Citazioni (Scopus)

Abstract

In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. New immunoassays able to detect biomarkers at ultralow levels have allowed for the measurement of NfL in blood, thus making it possible to easily and repeatedly measure NfL for monitoring diseases' courses. Evidence that both CSF and blood NfL may serve as diagnostic, prognostic and monitoring biomarkers in neurological diseases is progressively increasing, and NfL is one of the most promising biomarkers to be used in clinical and research setting in the next future. Here we review the most important results on CSF and blood NfL and we discuss its potential applications and future directions.
Lingua originaleEnglish
pagine (da-a)870-881
Numero di pagine12
RivistaJOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY
Volume90
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Biomarkers
  • Humans
  • Nervous System Diseases
  • Neurofilament Proteins
  • Parkinson's disease
  • Prognosis
  • dementia
  • motor neuron disease
  • multiple sclerosis
  • traumatic brain injury

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