Neurofibromatosis Type 1 Associated with Vertebrobasilar Dolichoectasia and Pontine Ischemic Stroke

Aldobrando Broccolini, Giuseppe Maria Di Lella, Giuseppe Zampino, Giacomo Della Marca, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Roberta Morosetti

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10 Citazioni (Scopus)


Neurofibromatosis type 1 (NF1) is a heterogeneous, common, neurocutaneous disorder presenting different complications during a life span, including cerebrovascular dysplasia. To our knowledge this is the first reported case of NF1 associated with vertebrobasilar dolichoectasia and pontine ischemic stroke. We describe a 57-year-old man with NF1 who presented an acute onset right-sided facial palsy and hemiplegia, dysarthria, and gait imbalance. Magnetic resonance imaging showed an acute left paramedian pontine infarct and a hypoplastic right vertebral artery. Brain Computed Tomography Angiography revealed the occurrence of vertebrobasilar dolichoectasia. Co-occurrence of VBD and NF1 might not be merely casual and it may significantly heighten the mortality rate in this multisystem disorder. We suggest a possible role of VBD in the genesis of our patient's clinical-radiological features and prompt the early detection of asymptomatic arteriopathy in individuals with NF1 in order to ameliorate patients' quality of life and life expectancy
Lingua originaleEnglish
pagine (da-a)505-506
Numero di pagine2
RivistaJournal of Neuroimaging
Stato di pubblicazionePubblicato - 2015


  • Neurofibromatosis
  • stroke
  • vertebrobasilar dolichoectasia


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