Neurodevelopmental Outcomes in Preterm Infants Receiving a Multicomponent vs. a Soybean-Based Lipid Emulsion: 24 Month Follow-Up of a Randomized Controlled Trial

Francesca Gallini, Maria Sofia Pelosi, Domenico Umberto De Rose, Maria Coppola, Simonetta Costa, Domenico Marco Maurizio Romeo, Carmen Cocca, Luca Maggio, Francesco Cota, Alessandra Piersanti, Daniela Ricci, Giovanni Vento

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Background: Few studies in the literature have analyzed the long-term neurodevelopmental outcomes of the administration of a multicomponent versus a soybean-based lipid emulsion (LE) in preterm infants receiving parenteral nutrition (PN). A recent randomized controlled trial conducted in our unit provided evidence of better growth in head circumference during the hospital stay in those who received a multicomponent LE. Methods: This is a 24 month follow-up study of preterm infants, previously enrolled in a randomized trial, who received a multicomponent LE (SMOFlipid((R))) or a standard soybean-based one (Intralipid((R))). We evaluated neurodevelopmental outcomes at 24 months of corrected age (CA) in the two groups. Results: Ninety-three children were followed up to the age of 24 months CA. Due to the peculiar time frame of the SARS-CoV-2 pandemic, neurodevelopmental outcomes were evaluated only in 77 children: 37 in the SMOFlipid((R)) group and 40 in the Intralipid((R)) group. No differences in major disability rates or in Griffith's evaluation were found between the two groups. Conclusions: In our population study, the administration of a multicomponent LE containing fish oil, compared to a soybean-based LE, had no significant effects on neurodevelopmental outcomes in preterm infants at 24 months CA.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaNutrients
Volume15
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • Griffith’s Mental Development Scales
  • Intralipid
  • SMOFlipid
  • multicomponent lipid emulsion
  • neonatal outcome
  • parenteral nutrition
  • preterm infants
  • very-low-birth-weight infants

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