Neurocutaneous melanosis in infancy: Always a dismal prognosis?

Federico Bianchi, Gianpiero Tamburrini, Cesare Colosimo, Luca Massimi, Paolo Frassanito

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)


AIM: To analyze the current literature on neurocutaneous melanosis (NCM), as well as, our cases, in order to better define the prognosis and the presence of risk factors affecting it, thus, offering better information to the parents. MATERIAL and METHODS: Two cases observed at the Pediatric Neurosurgery Unit of the Catholic University Medical School in Rome are described. Both of them had cutaneous stigmata and cerebral MR evidence of intracranial melanin deposits. These two children showed a very different clinical course. RESULTS: The present study enlighten the differences among the two cases and review the literature on the subject, with the attempt to understand which are clinical and disease related factors that might influence the prognosis. CONCLUSION: Beside malignant features of cutaneous melanotic lesions, the presence of hydrocephalus at diagnosis and the early appearance of clinical symptoms, when appearing contemporarily, are predicting the rapid progression of the disease and a worse prognosis.
Lingua originaleEnglish
pagine (da-a)476-482
Numero di pagine7
RivistaTurkish Neurosurgery
Stato di pubblicazionePubblicato - 2020


  • Child, Preschool
  • Female
  • Humans
  • Hydrocephalus
  • Infant
  • Male
  • Melanosis
  • Neurocutaneous Syndromes
  • Neurocutaneus melanosis
  • Personalized medicine
  • Prognosis


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