Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion

Giovambattista Pani, Virve Cavallucci, Marco Fidaleo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

31 Citazioni (Scopus)

Abstract

Adult neurogenesis initiated by neural stem cells (NSCs) contributes to brain homeostasis, damage repair, and cognition. Energy metabolism plays a pivotal role in neurogenic cell fate decisions regarding self-renewal, expansion and multilineage differentiation. NSCs need to fine-tune quiescence and proliferation/commitment to guarantee lifelong neurogenesis and avoid premature exhaustion. Accumulating evidence supports a model whereby calorie restriction or increased energy expenditure reinforce NSC quiescence and promote self-renewal. Conversely, growth/proliferation inputs and anabolic signals, although necessary for neurogenesis, deplete the NSCs pool in the long run. This framework incorporates the emerging neurogenic roles of nutrient-sensing signaling pathways, providing a rationale for the alarming connection between nutritional imbalances, metabolic disorders and accelerated brain aging.
Lingua originaleEnglish
pagine (da-a)756-769
Numero di pagine14
RivistaTrends in Endocrinology and Metabolism
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • adult neurogenesis
  • brain aging
  • metabolism
  • neural stem cells (NSC)
  • self-renewal

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