TY - JOUR
T1 - Neural correlates of cognitive control in gambling disorder: a systematic review of fMRI studies
AU - Moccia, Lorenzo
AU - Pettorruso, Mauro
AU - De Crescenzo, Franco
AU - De Risio, Luisa
AU - Di Nuzzo, Luigi
AU - Martinotti, Giovanni
AU - Bifone, Angelo
AU - Janiri, Luigi
AU - Di Nicola, Marco
PY - 2017
Y1 - 2017
N2 - Decreased cognitive control over the urge to be involved in gambling activities is a core feature of Gambling Disorder (GD). Cognitive control can be differentiated into several cognitive sub-processes pivotal in GD clinical phenomenology, such as response inhibition, conflict monitoring, decision-making, and cognitive flexibility. This article aims to systematically review fMRI studies, which investigated the neural mechanisms underlying diminished cognitive control in GD. We conducted a comprehensive literature search and collected neuropsychological and neuroimaging data investigating cognitive control in GD. We included a total of 14 studies comprising 499 individuals. Our results indicate that impaired activity in prefrontal cortex may account for decreased cognitive control in GD, contributing to the progressive loss of control over gambling urges. Among prefrontal regions, orbital and ventromedial areas seem to be a possible nexus for sensory integration, value-based decision-making and emotional processing, thus contributing to both motivational and affective aspects of cognitive control. Finally, we discussed possible therapeutic approaches aimed at the restoration of cognitive control in GD, including pharmacological and brain stimulation treatments.
AB - Decreased cognitive control over the urge to be involved in gambling activities is a core feature of Gambling Disorder (GD). Cognitive control can be differentiated into several cognitive sub-processes pivotal in GD clinical phenomenology, such as response inhibition, conflict monitoring, decision-making, and cognitive flexibility. This article aims to systematically review fMRI studies, which investigated the neural mechanisms underlying diminished cognitive control in GD. We conducted a comprehensive literature search and collected neuropsychological and neuroimaging data investigating cognitive control in GD. We included a total of 14 studies comprising 499 individuals. Our results indicate that impaired activity in prefrontal cortex may account for decreased cognitive control in GD, contributing to the progressive loss of control over gambling urges. Among prefrontal regions, orbital and ventromedial areas seem to be a possible nexus for sensory integration, value-based decision-making and emotional processing, thus contributing to both motivational and affective aspects of cognitive control. Finally, we discussed possible therapeutic approaches aimed at the restoration of cognitive control in GD, including pharmacological and brain stimulation treatments.
KW - Affective processing
KW - Behavioral Neuroscience
KW - Cognitive Neuroscience
KW - Cognitive flexibility
KW - Conflict monitoring
KW - Delay discounting
KW - Impulsivity
KW - Iowa Gambling Task
KW - Neuropsychology and Physiological Psychology
KW - Orbitofrontal cortex
KW - Pathological gambling
KW - Prefrontal cortex
KW - Response inhibition
KW - Reversal learning
KW - Transcranial magnetic stimulation
KW - Value-based decision-making
KW - Affective processing
KW - Behavioral Neuroscience
KW - Cognitive Neuroscience
KW - Cognitive flexibility
KW - Conflict monitoring
KW - Delay discounting
KW - Impulsivity
KW - Iowa Gambling Task
KW - Neuropsychology and Physiological Psychology
KW - Orbitofrontal cortex
KW - Pathological gambling
KW - Prefrontal cortex
KW - Response inhibition
KW - Reversal learning
KW - Transcranial magnetic stimulation
KW - Value-based decision-making
UR - http://hdl.handle.net/10807/106665
UR - http://www.elsevier.com/locate/neubiorev
U2 - 10.1016/j.neubiorev.2017.04.025
DO - 10.1016/j.neubiorev.2017.04.025
M3 - Article
SN - 0149-7634
VL - 78
SP - 104
EP - 116
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -