Neonatal transient pseudohypoparathyroidism: Could it be included among inactivating parathyroid hormone (PTH)/PTH-related protein signalling disorders?

Francesca Gallini, Giovanni Vento, Domenico Umberto De Rose, Eloisa Tiberi, Enrico Zecca

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

We report a case of transient pseudohypoparathyroidism in a full-term newborn that presented at 20 hours of life with hypocalcemic seizures, hyperphosphatemia and raised parathormone levels. The diagnosis of pseudohypoparathyroidism was made according to biochemical investigations. The infant was treated with calcium supplementation and vitamin D analog therapy, and he remained stable and symptom-free with normal serum biochemistries during follow-up. We suggest that transient pseudohypoparathyroidism of the newborn (ntPHP) might be included among inactivating parathyroid hormone (PTH)/PTH-related protein signaling disorders as defined by the classification schema recently proposed by the European Pseudohypoparathyroidism Network. To the best of our knowledge, this is the first report in which the new classification has been applied to a case of ntPHP.
Lingua originaleEnglish
pagine (da-a)129-132
Numero di pagine4
RivistaANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume24
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Hypocalcemic seizures
  • Inactivating PTH/PTH-related protein signaling disorder
  • Newborn
  • Personalized medicine
  • Pseudohypoparathyroidism

Fingerprint

Entra nei temi di ricerca di 'Neonatal transient pseudohypoparathyroidism: Could it be included among inactivating parathyroid hormone (PTH)/PTH-related protein signalling disorders?'. Insieme formano una fingerprint unica.

Cita questo