Neonatal hypoglycemia and neurodevelopmental outcomes: Yesterday, today, tomorrow

D. U. De Rose, A. Perri, Luca Maggio, G. Salvatori, A. Dotta, Giovanni Vento, Francesca Gallini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Neonatal hypoglycemia is a major source of concern for pediatricians since it has commonly been related to poor neurodevelopmental outcomes. Diagnosis is challenging, considering the different operational thresholds provided by each guideline. Screening of infants at risk plays a crucial role, considering that most hypoglycemic infants show no clinical signs. New opportunities for prevention and treatment are provided by the use of oral dextrose gel. Continuous glucose monitoring systems could be a feasible tool in the next future. Furthermore, there is still limited evidence to underpin the current clinical practice of administering, in case of hypoglycemia, an intravenous “mini-bolus” of 10% dextrose before starting a continuous dextrose infusion. This brief review provides an overview of the latest advances in this field and neurodevelopmental outcomes according to different approaches. Conclusion: To adequately define if a more permissive approach is risk-free for neurodevelopmental outcomes, more research on continuous glucose monitoring and long-term follow-up is still needed. (Table presented.)
Lingua originaleEnglish
pagine (da-a)1113-1119
Numero di pagine7
RivistaEuropean Journal of Pediatrics
Volume183
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • Continuous glucose monitoring
  • Threshold
  • Newborn
  • Glucose

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