Neoadjuvant chemotherapy for patients with muscle-invasive urothelial bladder cancer candidates for curative surgery: A prospective clinical trial based on cisplatin feasibility

Giovanni Schinzari, Santa Monterisi, Francesco Pierconti, Giulia Nazzicone, Laura Marandino, Armando Orlandi, Marco Racioppi, Alessandra Cassano, Pierfrancesco Bassi, Carlo Antonio Barone, Ernesto Rossi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Background: Neoadjuvant chemotherapy demonstrated a survival benefit versus cystectomy alone in muscle-invasive urothelial bladder cancer. Despite this advantage, preoperative chemotherapy is not widely employed. When patients are unfit for cisplatin-based regimen, they are often candidates for immediate surgery. In our study, patients with muscle-invasive bladder cancer were treated with neoadjuvant chemotherapy. The principal objective was the rate of complete pathological response (PCR). Secondary end-points were disease-free survival (DFS), overall survival (OS) and toxicity. Patients and Methods: Patients (n=72) with Eastern Cooperative Oncology Group (ECOG) performance status 0-1, clinical stage cT3-4, and/or N+ muscle-invasive bladder cancer were enrolled. The chemotherapy regimen was established according to the cisplatin feasibility. Thirty patients were treated with cisplatin/gemcitabine (Gem) and 42 with carboplatin/Gem. Results: The rate of PCR was 29.2%, 36% with cisplatin-based treatment and 23.8% with carboplatin (p=0.3574). DFS and OS were longer in PCR patients, while no difference was reported between cisplatin/Gem and Carboplatin/Gem groups. Conclusion: Our results confirm the prognostic value of PCR in neoadjuvant chemotherapy for muscle-invasive bladder cancer. When the patients are not fit for cisplatin, a carboplatin/Gem regimen represents a valid option because of comparable long-term outcome. When cisplatin is not feasible, the exclusion of a preoperative treatment is not justified.
Lingua originaleEnglish
pagine (da-a)6453-6458
Numero di pagine6
RivistaAnticancer Research
Volume37
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Cancer Research
  • Carboplatin
  • Carcinoma, Transitional Cell
  • Cisplatin
  • Cystectomy
  • Deoxycytidine
  • Disease-Free Survival
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoadjuvant
  • Neoadjuvant Therapy
  • Oncology
  • Pathological response
  • Prospective Studies
  • Survival Analysis
  • Treatment Outcome
  • Urinary Bladder Neoplasms
  • Urothelial bladder cancer

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