Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives

Alberto Biondi, Domenico D'Ugo, Riccardo Ricci, Roberto Persiani, Maria Carmen Lirosi, Valeria Fico, Francesco Santullo, Ferdinando Carlo Maria Cananzi, Antonia Rizzuto, Ferdinando Cm Cananzi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

16 Citazioni (Scopus)

Abstract

In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules.
Lingua originaleEnglish
pagine (da-a)389-400
Numero di pagine12
RivistaWorld Journal of Gastrointestinal Oncology
Volume7
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Chemotherapy
  • Gastric Cancer
  • Neo-adjuvant treatment
  • Radiotherapy

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