Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis

Raffaele Manna, M Salvatore, Flavia Scuderi, Giuseppina Papa, Giovanni Marietti, Av Greco, Giovanni Ghirlanda, Giovanni Gambassi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)


We have studied 27 insulin-dependent diabetic patients since diagnosis for a period of six months; at diabetes onset and later on, ICA were found in 17 of them, whereas they were undetectable in 10 patients: age was remarkably homogeneous in the two groups. At diabetes onset, no significant differences were found in insulin requirement between ICA positive and ICA negative patients; however, six months after diagnosis, we observed that insulin requirement to keep metabolic control was significantly higher in ICA positive than in ICA negative subjects (0.515 +/- 0.2 U/Kg versus 0.22 +/- 0.15 U/Kg, p less than 0.001). Only one remission has been detected in ICA positive group (insulin requirement less than 0.25 U/Kg), while four ICA negative patients had complete remission and three had partial remission. ICA positive patients showed fasting C-peptide values higher than ICA negative (0.5 +/- 0.28 ng/ml versus 1.4 +/- 0.5 ng/m.; p less than 0.001, at rest; 1.1 +/- 0.6 ng/ml; versus 2.6 +/- 1.0 ng/ml, 6 minutes after stimulus; p less than 0.05). Our study suggests that presence and persistence of ICA may be considered an early and predictive marker for a worse beta cell function restoration resulting in a higher insulin requirement.
Lingua originaleEnglish
pagine (da-a)101-103
Numero di pagine3
RivistaDiabetes research (Edinburgh, Scotland)
Stato di pubblicazionePubblicato - 1988


  • Adolescent
  • Autoantibodies
  • C-Peptide
  • Diabetes Mellitus, Type 1
  • Female
  • Follow-Up Studies
  • HLA Antigens
  • Humans
  • Insulin
  • Islets of Langerhans
  • Male


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