TY - JOUR
T1 - Navigating the nano-bioimmune interface: advancements and challenges in CNS nanotherapeutics
AU - Moulton, Chantalle
AU - Baroni, Anna
AU - Quagliarini, Erica
AU - Leone, Lucia
AU - Digiacomo, Luca
AU - Caracciolo, Giulio
AU - Podda, Maria Vittoria
AU - Tasciotti, Ennio
PY - 2024
Y1 - 2024
N2 - In recent years, significant advancements have been made in utilizing
nanoparticles (NPs) to modulate immune responses within the central nervous
system (CNS), offering new opportunities for nanotherapeutic interventions in
neurological disorders. NPs can serve as carriers for immunomodulatory agents
or platforms for delivering nucleic acid-based therapeutics to regulate gene
expression and modulate immune responses. Several studies have demonstrated
the efficacy of NP-mediated immune modulation in preclinical models of
neurological diseases, including multiple sclerosis, stroke, Alzheimer’s disease,
and Parkinson’s disease. While challenges remain, advancements in NPs
engineering and design have led to the development of NPs using diverse
strategies to overcome these challenges. The nano-bio interface with the
immune system is key in the conceptualization of NPs to efficiently act as
nanotherapeutics in the CNS. The biomolecular corona plays a pivotal role in
dictating NPs behavior and immune recognition within the CNS, giving
researchers the opportunity to optimize NPs design and surface modifications
to minimize immunogenicity and enhance biocompatibility. Here, we review
how NPs interact with the CNS immune system, focusing on immunosurveillance
of NPs, NP-induced immune reprogramming and the impact of the biomolecular
corona on NPs behavior in CNS immune responses. The integration of NPs into
CNS nanotherapeutics offers promising opportunities for addressing the
complex challenges of acute and chronic neurological conditions and
pathologies, also in the context of preventive and rehabilitative medicine. By
harnessing the nano-bio immune interface and understanding the significance of
the biomolecular corona, researchers can develop targeted, safe, and effective
nanotherapeutic interventions for a wide range of CNS disorders to improve
treatment and rehabilitation. These advancements have the potential to
revolutionize the treatment landscape of neurological diseases, offering
promising solutions for improved patient care and quality of life in the future.
AB - In recent years, significant advancements have been made in utilizing
nanoparticles (NPs) to modulate immune responses within the central nervous
system (CNS), offering new opportunities for nanotherapeutic interventions in
neurological disorders. NPs can serve as carriers for immunomodulatory agents
or platforms for delivering nucleic acid-based therapeutics to regulate gene
expression and modulate immune responses. Several studies have demonstrated
the efficacy of NP-mediated immune modulation in preclinical models of
neurological diseases, including multiple sclerosis, stroke, Alzheimer’s disease,
and Parkinson’s disease. While challenges remain, advancements in NPs
engineering and design have led to the development of NPs using diverse
strategies to overcome these challenges. The nano-bio interface with the
immune system is key in the conceptualization of NPs to efficiently act as
nanotherapeutics in the CNS. The biomolecular corona plays a pivotal role in
dictating NPs behavior and immune recognition within the CNS, giving
researchers the opportunity to optimize NPs design and surface modifications
to minimize immunogenicity and enhance biocompatibility. Here, we review
how NPs interact with the CNS immune system, focusing on immunosurveillance
of NPs, NP-induced immune reprogramming and the impact of the biomolecular
corona on NPs behavior in CNS immune responses. The integration of NPs into
CNS nanotherapeutics offers promising opportunities for addressing the
complex challenges of acute and chronic neurological conditions and
pathologies, also in the context of preventive and rehabilitative medicine. By
harnessing the nano-bio immune interface and understanding the significance of
the biomolecular corona, researchers can develop targeted, safe, and effective
nanotherapeutic interventions for a wide range of CNS disorders to improve
treatment and rehabilitation. These advancements have the potential to
revolutionize the treatment landscape of neurological diseases, offering
promising solutions for improved patient care and quality of life in the future.
KW - biomolecular corona
KW - central nervous system
KW - immune reprogramming
KW - molecular rehabilitation
KW - nanoparticles
KW - nanotherapeutics
KW - biomolecular corona
KW - central nervous system
KW - immune reprogramming
KW - molecular rehabilitation
KW - nanoparticles
KW - nanotherapeutics
UR - http://hdl.handle.net/10807/299656
U2 - 10.3389/fimmu.2024.1447567
DO - 10.3389/fimmu.2024.1447567
M3 - Article
SN - 1664-3224
VL - 15
SP - 1
EP - 19
JO - Frontiers in Immunology
JF - Frontiers in Immunology
ER -