Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

Loredana Ruggeri, Luca Vago, Diderik-Jan Eikema, Liesbeth C. De Wreede, Fabio Ciceri, Miguel Angel Diaz, Franco Locatelli, Pavel Jindra, Giuseppe Milone, Josè Luis Diez-Martin, Jose Antonio Pérez-Simón, Mara Merluzzi, Linda Koster, Steffie Van Der Werf, Anja Van Biezen, Antoine Toubert, Arnon Nagler, Christian Chabannon, Chiara Bonini, Andrea Velardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Human leukocyte antigen (HLA) class-I mismatches that trigger donor-versus-recipient natural killer (NK)-cell alloreactivity reduce the incidence of leukemia relapse and improve survival of acute myeloid leukemia patients after T-cell-depleted HLA-haplotype mismatched (“haploidentical”) hematopoietic transplantation. In murine graft-versus-host disease (GvHD) models, alloreactive NK-cells also prevent GvHD. Here we report the results of a non-interventional, prospective study performed on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation. The study was aimed at re-assessing the role of NK-cell alloreactivity in a cohort of haploidentical transplants performed in Europe between 2012 and 2015 and composed of unmanipulated, as well as T-cell-depleted transplants. One hundred thirty-eight patients with acute myeloid or lymphoid leukemias were analyzed. Eighty-six patients received ex-vivo T-cell-depleted transplants, 52 patients received unmanipulated transplants. Fifty patients were transplanted from NK alloreactive donors, 88 from non-NK alloreactive donors. NK cell alloreactivity did not impact on GvHD/relapse-free survival (GRFS) in unmanipulated transplants (HR: 1.66 (0.9–3.1), p = 0.1). In contrast, it did impact beneficially on GRFS in T-cell-depleted transplants (HR: 0.6, (0.3–1.2), p = 0.14, interaction p < 0.001). This effect was the consequence of reduced incidences of acute and chronic GvHD and non-relapse mortality.
Lingua originaleEnglish
pagine (da-a)1900-1907
Numero di pagine8
RivistaBone Marrow Transplantation
Stato di pubblicazionePubblicato - 2021


  • NK


Entra nei temi di ricerca di 'Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT'. Insieme formano una fingerprint unica.

Cita questo