Natural evolution of skin-test sensitivity in patients with IgE-mediated hypersensitivity to cephalosporins

A. Romano, Antonino Romano, F. Gaeta, R. L. Valluzzi, A. Zaffiro, C. Caruso, D. Quaratino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

46 Citazioni (Scopus)


There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospectively in a 5-year follow-up 72 cephalosporin-allergic patients. After the first evaluation, patients were classified into two groups according to their patterns of allergologic-test positivity: to both penicillins and cephalosporins (group A), or only to cephalosporins (group B). Skin tests and serum-specific IgE assays were repeated 1 year later and, in case of persistent positivity, 3 and 5 years after the first allergologic examination. Seven (43.7%) of the 16 subjects of group A and 38 (67.8%) of the 56 patients of group B became negative; one was lost to follow-up. Patients of group B became negative sooner and more frequently than group A subjects.
Lingua originaleEnglish
pagine (da-a)806-809
Numero di pagine4
Stato di pubblicazionePubblicato - 2014


  • Adult
  • Anti-Bacterial Agents
  • Cephalosporins
  • Drug Hypersensitivity
  • Female
  • Humans
  • Hypersensitivity, Immediate
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Skin Tests
  • Young Adult
  • cephalosporin allergy
  • follow-up
  • skin tests


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