Naloxone inhibition of postprandial growth hormone releasing hormone-induced growth hormone release in obesity

Antonio Mancini, Salvatore Maria Corsello, Laura De Marinis Grasso, Antonino Barbarino, G Folli, C D'Amico, R Sciuto, A Tofani, P Sambo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low, while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting 1 h before GHRH administration (50 micrograms i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release. In normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.
Lingua originaleEnglish
pagine (da-a)529-532
Numero di pagine4
RivistaNeuroendocrinology
Volume50
Stato di pubblicazionePubblicato - 1989

Keywords

  • Adult
  • Eating
  • Female
  • Growth Hormone
  • Growth Hormone-Releasing Hormone
  • Humans
  • Naloxone
  • Obesity
  • Receptors, Opioid

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