n-3 polyunsaturated fatty acid effect in periodontal disease: state of art, future perspectives and possible mechanisms involved

Luca Raffaelli, Simona Serini, Paolo Francesco Manicone, Gabriella Calviello, Elisabetta Piccioni, D. Berardi, G. Perfetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

20 Citazioni (Scopus)

Abstract

Anti-inflammatory properties have been widely reported for n-3 polyunsaturated fatty acids (PUFAs) and some studies have been focalized on their possible role in the modulation of gingivitis and alveolar bone resorption in periodontal disease (PD). Increased formation of arachidonic acid-derived inflammatory eicosanoids and augmented oxidative stress are two molecular mechanisms pathogenetically involved in the progression of PD and known to be inhibited by n-3 PUFAs in P setting. The present review will focus also on other molecular pathways and factors known to be altered in the development of PD and known to be subject to n-3 PUFA modulation in other pathological settings different from PD. Overall, the available findings strongly encourage further experimental studies on animals subject to experimental PD and treated with n-3 PUFAs, long term n-3 PUFA intervention studies on PD patients and molecular studies to identify additional potential molecular routes of n-3 PUFA action in PD.
Lingua originaleEnglish
pagine (da-a)261-266
Numero di pagine6
RivistaInternational Journal of Immunopathology and Pharmacology
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • inflammation
  • n-3 PUFA
  • periodontal disease

Fingerprint Entra nei temi di ricerca di 'n-3 polyunsaturated fatty acid effect in periodontal disease: state of art, future perspectives and possible mechanisms involved'. Insieme formano una fingerprint unica.

Cita questo