Myocardial Revascularization Trials Beyond the Printed Word

Mario Fulvio Luigi Gaudino, Marc Ruel, Volkmar Falk, Michael E. Farkouh, Nick Freemantle, David Glineur, Duke E. Cameron, David P. Taggart

Risultato della ricerca: Contributo in rivistaArticolo in rivista

25 Citazioni (Scopus)

Abstract

This article reviews the context and evidence of recent myocardial revascularization trials that compared percutaneous coronary intervention with coronary artery bypass grafting for the treatment of left main and multivessel coronary artery disease. We develop the rationale that some of the knowledge synthesis resulting from these trials, particularly with regard to the claimed noninferiority of percutaneous coronary intervention beyond nondiabetic patients with low anatomic complexity, may have been affected by trial design, patient selection based on suitability for percutaneous coronary intervention, and end point optimization favoring percutaneous coronary intervention over coronary artery bypass grafting. We provide recommendations that include holding a circumspect interpretation of the currently available evidence, as well as suggestions for the collaborative design and conduct of future clinical trials in this and other fields.
Lingua originaleEnglish
pagine (da-a)2943-2951
Numero di pagine9
RivistaCirculation
Volume138
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • clinical trials as topic
  • coronary artery disease
  • coronary stenosis
  • percutaneous coronary intervention
  • surgical procedures, operative
  • treatment outcomes

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