[Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis]

Giovanni Gambassi, Pierugo Carbonin, Mc Capogrossi, A Mugelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.
Titolo tradotto del contributo[Autom. eng. transl.] [Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis]
Lingua originaleItalian
pagine (da-a)591-593
Numero di pagine3
RivistaCardiologia
Volume37
Stato di pubblicazionePubblicato - 1992

Keywords

  • Animals
  • Calcium
  • Fluorescence
  • Fluorescent Dyes
  • Heart
  • Homeostasis
  • Hypothermia, Induced
  • Indoles
  • Rats
  • Sarcoplasmic Reticulum

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