Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and
acute coronary syndromes.

Valentina Loria; Ilaria Dato; Francesca Graziani; Luigi Marzio Biasucci

doi:10.1155/2008/135625

Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes.

Valentina Loria, Ilaria Dato, Francesca Graziani, Luigi Marzio Biasucci

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Mediators of Inflammation
DOI	https://doi.org/10.1155/2008/135625
Stato di pubblicazione	Pubblicato - 2008

Keywords

myeloperoxidase

Accesso al documento

10.1155/2008/135625

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title = "Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes.",

abstract = "Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).",

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AU - Loria, Valentina

AU - Dato, Ilaria

AU - Graziani, Francesca

AU - Biasucci, Luigi Marzio

PY - 2008

Y1 - 2008

N2 - Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).

AB - Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).

KW - myeloperoxidase

UR - http://hdl.handle.net/10807/232878

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DO - 10.1155/2008/135625

M3 - Article

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SP - N/A-N/A

JO - Mediators of Inflammation

JF - Mediators of Inflammation