Myelodysplastic disorders carrying both isolated del(5q) and JAK2(V617F) mutation: concise review, with focus on lenalidomide therapy

Emiliano Fabiani, Maria Teresa Voso, Pellegrino Musto, Vittorio Simeon, Roberto Guariglia, Gabriella Bianchino, Vitina Grieco, Filomena Nozza, Francesco La Rocca, Gioacchino Marziano, Anna Vittoria Lalinga, Patrizia Scaravaglio, Cristina Mecucci, Giovanni D'Arena

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

The concomitant presence of del(5q) and JAK2(V617F) mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neoplasms. Lenalidomide may induce rapid, profound, and long-lasting responses in a subset of these patients. However, the mechanism(s) by which the drug acts in these conditions remain not completely elucidated. A new case report and a review of all cases published so far in this setting are provided. Furthermore, the possibility of categorizing - from a clinical, pathological, and biological point of view - for at least some of these patients as a potential distinct entity is discussed.
Lingua originaleEnglish
pagine (da-a)1043-1050
Numero di pagine8
RivistaOnco Targets Ther
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • JAK2
  • del(5q)

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