MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

A. I. Tsonis; Amelia Evoli Stampanoni-B; P. Zisimopoulou; K. Lazaridis; J. Tzartos; E. Matsigkou; V. Zouvelou; R. Mantegazza; C. Antozzi; F. Andreetta; F. Deymeer; G. Saruhan-Direskeneli; H. Durmus; T. Brenner; A. Vaknin; S. Berrih-Aknin; A. Behin; T. Sharshar; M. De Baets; M. Losen; P. Martinez-Martinez; K. A. Kleopa; E. Zamba-Papanicolaou; T. Kyriakides; A. Kostera-Pruszczyk; P. Szczudlik; B. Szyluk; D. Lavrnic; I. Basta; S. Peric; C. Tallaksen; A. Maniaol; C. Casasnovas Pons; J. Pitha; M. Jakubíkova; F. Hanisch; S. J. Tzartos

doi:10.1016/j.jneuroim.2015.04.015

MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

A. I. Tsonis, Amelia Evoli Stampanoni-B, P. Zisimopoulou, K. Lazaridis, J. Tzartos, E. Matsigkou, V. Zouvelou, R. Mantegazza, C. Antozzi, F. Andreetta, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. LosenP. Martinez-Martinez, K. A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, S. J. Tzartos

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

40 Citazioni (Scopus)

Abstract

Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

Lingua originale	English
pagine (da-a)	10-17
Numero di pagine	8
Rivista	Journal of Neuroimmunology
Volume	284
DOI	https://doi.org/10.1016/j.jneuroim.2015.04.015
Stato di pubblicazione	Pubblicato - 2015

Keywords

Autoantibodies
Cell-based assay
MuSK
Myasthenia gravis

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10.1016/j.jneuroim.2015.04.015

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Tsonis, A. I., Evoli Stampanoni-B, A., Zisimopoulou, P., Lazaridis, K., Tzartos, J., Matsigkou, E., Zouvelou, V., Mantegazza, R., Antozzi, C., Andreetta, F., Deymeer, F., Saruhan-Direskeneli, G., Durmus, H., Brenner, T., Vaknin, A., Berrih-Aknin, S., Behin, A., Sharshar, T., De Baets, M., ... Tzartos, S. J. (2015). MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study. Journal of Neuroimmunology, 284, 10-17. https://doi.org/10.1016/j.jneuroim.2015.04.015

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title = "MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study",

abstract = "Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.",

keywords = "Autoantibodies, Cell-based assay, MuSK, Myasthenia gravis, Autoantibodies, Cell-based assay, MuSK, Myasthenia gravis",

author = "Tsonis, {A. I.} and {Evoli Stampanoni-B}, Amelia and P. Zisimopoulou and K. Lazaridis and J. Tzartos and E. Matsigkou and V. Zouvelou and R. Mantegazza and C. Antozzi and F. Andreetta and F. Deymeer and G. Saruhan-Direskeneli and H. Durmus and T. Brenner and A. Vaknin and S. Berrih-Aknin and A. Behin and T. Sharshar and {De Baets}, M. and M. Losen and P. Martinez-Martinez and Kleopa, {K. A.} and E. Zamba-Papanicolaou and T. Kyriakides and A. Kostera-Pruszczyk and P. Szczudlik and B. Szyluk and D. Lavrnic and I. Basta and S. Peric and C. Tallaksen and A. Maniaol and {Casasnovas Pons}, C. and J. Pitha and M. Jakub{\'i}kova and F. Hanisch and Tzartos, {S. J.}",

year = "2015",

doi = "10.1016/j.jneuroim.2015.04.015",

language = "English",

volume = "284",

pages = "10--17",

journal = "Journal of Neuroimmunology",

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publisher = "Elsevier B.V.",

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Tsonis, AI, Evoli Stampanoni-B, A, Zisimopoulou, P, Lazaridis, K, Tzartos, J, Matsigkou, E, Zouvelou, V, Mantegazza, R, Antozzi, C, Andreetta, F, Deymeer, F, Saruhan-Direskeneli, G, Durmus, H, Brenner, T, Vaknin, A, Berrih-Aknin, S, Behin, A, Sharshar, T, De Baets, M, Losen, M, Martinez-Martinez, P, Kleopa, KA, Zamba-Papanicolaou, E, Kyriakides, T, Kostera-Pruszczyk, A, Szczudlik, P, Szyluk, B, Lavrnic, D, Basta, I, Peric, S, Tallaksen, C, Maniaol, A, Casasnovas Pons, C, Pitha, J, Jakubíkova, M, Hanisch, F & Tzartos, SJ 2015, 'MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study', Journal of Neuroimmunology, vol. 284, pagg. 10-17. https://doi.org/10.1016/j.jneuroim.2015.04.015

TY - JOUR

T1 - MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

AU - Tsonis, A. I.

AU - Evoli Stampanoni-B, Amelia

AU - Zisimopoulou, P.

AU - Lazaridis, K.

AU - Tzartos, J.

AU - Matsigkou, E.

AU - Zouvelou, V.

AU - Mantegazza, R.

AU - Antozzi, C.

AU - Andreetta, F.

AU - Deymeer, F.

AU - Saruhan-Direskeneli, G.

AU - Durmus, H.

AU - Brenner, T.

AU - Vaknin, A.

AU - Berrih-Aknin, S.

AU - Behin, A.

AU - Sharshar, T.

AU - De Baets, M.

AU - Losen, M.

AU - Martinez-Martinez, P.

AU - Kleopa, K. A.

AU - Zamba-Papanicolaou, E.

AU - Kyriakides, T.

AU - Kostera-Pruszczyk, A.

AU - Szczudlik, P.

AU - Szyluk, B.

AU - Lavrnic, D.

AU - Basta, I.

AU - Peric, S.

AU - Tallaksen, C.

AU - Maniaol, A.

AU - Casasnovas Pons, C.

AU - Pitha, J.

AU - Jakubíkova, M.

AU - Hanisch, F.

AU - Tzartos, S. J.

PY - 2015

Y1 - 2015

N2 - Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

AB - Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

KW - Autoantibodies

KW - Cell-based assay

KW - MuSK

KW - Myasthenia gravis

KW - Autoantibodies

KW - Cell-based assay

KW - MuSK

KW - Myasthenia gravis

UR - http://hdl.handle.net/10807/71472

U2 - 10.1016/j.jneuroim.2015.04.015

DO - 10.1016/j.jneuroim.2015.04.015

M3 - Article

SN - 0165-5728

VL - 284

SP - 10

EP - 17

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

MuSK autoantibodies in myasthenia gravis detected by cell based assay-A multinational study

Abstract

Keywords

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