Muscle histology vs MRI in Duchenne muscular dystrophy

Eugenio Maria Mercuri, M. Kinali, V. Arechavala-Gomeza, S. Cirak, A. Glover, M. Guglieri, L. Feng, K. G. Hollingsworth, D. Hunt, H. Jungbluth, H. P. Roper, R. M. Quinlivan, J. A. Gosalakkal, S. Jayawant, A. Nadeau, L. Hughes-Carre, A. Y. Manzur, J. E. Morgan, V. Straub, K. BushbyC. Sewry, M. Rutherford, F. Muntoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

100 Citazioni (Scopus)

Abstract

There are currently no effective treatments to halt the muscle breakdown in Duchenne muscular dystrophy (DMD), although genetic-based clinical trials are being piloted. Most of these trials have as an endpoint the restoration of dystrophin in muscle fibers, hence requiring sufficiently well-preserved muscle of recruited patients. The choice of the muscles to be studied and the role of noninvasive methods to assess muscle preservation therefore require further evaluation.
Lingua originaleEnglish
pagine (da-a)346-353
Numero di pagine8
RivistaNeurology
Volume76
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adolescent
  • Child
  • Foot
  • Humans
  • Leg
  • Magnetic Resonance Imaging
  • Male
  • Muscle, Skeletal
  • Muscular Dystrophy, Duchenne

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