Muscle derangement and alteration of the nutritional machinery in NSCLC

Giampaolo Tortora, Emilio Bria, Ilaria Trestini, Anastasios Gkountakos, Alice Avancini, Massimo Lanza, Alessio Molfino, Simonetta Friso, Vincenzo Corbo, Aldo Scarpa, Michele Milella, Sara Pilotto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Weight loss and depletion of nutritional status are frequent presentation hallmarks in non-small cell lung cancer (NSCLC). Decline in muscle mass is a major component in weight loss and may have both a prognostic and predictive value for survival and treatment-related toxicities. Recent findings suggest that weight and skeletal muscle mass gain during treatment may represent surrogate markers for outcome in advanced NSCLC patients. Herein we present an in-depth view of the impact of nutritional status derangements on NSCLC patients’ outcome, focusing on lean body mass variations during disease course. We explored the impact of malnutrition with a major attention on novel treatment options. We reviewed molecular, metabolic and immunological mechanisms underlying muscle-wasting condition, which may exhibit a meaningful targeting potential. Incorporating a specialized and accurate body composition assessment into a comprehensive, patient-centered and tailored intervention will facilitate the achievement of nutritional goals and optimal care for lung cancer patients.
Lingua originaleEnglish
pagine (da-a)43-53
Numero di pagine11
RivistaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume141
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Body composition
  • Muscle wasting
  • Non-small cell lung cancer
  • Nutritional status
  • Weight loss

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