TY - JOUR
T1 - Multivariate Patterns of Brain-Behavior-Environment Associations in the Adolescent Brain and Cognitive Development Study
AU - Modabbernia, Amirhossein
AU - Janiri, Delfina
AU - Doucet, Gaelle E
AU - Reichenberg, Abraham
AU - Frangou, Sophia
PY - 2021
Y1 - 2021
N2 - Background: Adolescence is a critical developmental stage. A key challenge is to characterize how variation in adolescent brain organization relates to psychosocial and environmental influences. Methods: We used canonical correlation analysis to discover distinct patterns of covariation between measures of brain organization (brain morphometry, intracortical myelination, white matter integrity, and resting-state functional connectivity) and individual, psychosocial, and environmental factors in a nationally representative U.S. sample of 9623 individuals (aged 9–10 years, 49% female) participating in the Adolescent Brain and Cognitive Development (ABCD) study. Results: These analyses identified 14 reliable modes of brain-behavior-environment covariation (canonical rdiscovery =.21 to.49, canonical rtest =.10 to.39, pfalse discovery rate corrected <.0001). Across modes, neighborhood environment, parental characteristics, quality of family life, perinatal history, cardiometabolic health, cognition, and psychopathology had the most consistent and replicable associations with multiple measures of brain organization; positive and negative exposures converged to form patterns of psychosocial advantage or adversity. These showed modality-general, respectively positive or negative, associations with brain structure and function with little evidence of regional specificity. Nested within these cross-modal patterns were more specific associations between prefrontal measures of morphometry, intracortical myelination, and functional connectivity with affective psychopathology, cognition, and family environment. Conclusions: We identified clusters of exposures that showed consistent modality-general associations with global measures of brain organization. These findings underscore the importance of understanding the complex and intertwined influences on brain organization and mental function during development and have the potential to inform public health policies aiming toward interventions to improve mental well-being.
AB - Background: Adolescence is a critical developmental stage. A key challenge is to characterize how variation in adolescent brain organization relates to psychosocial and environmental influences. Methods: We used canonical correlation analysis to discover distinct patterns of covariation between measures of brain organization (brain morphometry, intracortical myelination, white matter integrity, and resting-state functional connectivity) and individual, psychosocial, and environmental factors in a nationally representative U.S. sample of 9623 individuals (aged 9–10 years, 49% female) participating in the Adolescent Brain and Cognitive Development (ABCD) study. Results: These analyses identified 14 reliable modes of brain-behavior-environment covariation (canonical rdiscovery =.21 to.49, canonical rtest =.10 to.39, pfalse discovery rate corrected <.0001). Across modes, neighborhood environment, parental characteristics, quality of family life, perinatal history, cardiometabolic health, cognition, and psychopathology had the most consistent and replicable associations with multiple measures of brain organization; positive and negative exposures converged to form patterns of psychosocial advantage or adversity. These showed modality-general, respectively positive or negative, associations with brain structure and function with little evidence of regional specificity. Nested within these cross-modal patterns were more specific associations between prefrontal measures of morphometry, intracortical myelination, and functional connectivity with affective psychopathology, cognition, and family environment. Conclusions: We identified clusters of exposures that showed consistent modality-general associations with global measures of brain organization. These findings underscore the importance of understanding the complex and intertwined influences on brain organization and mental function during development and have the potential to inform public health policies aiming toward interventions to improve mental well-being.
KW - ABCD study
KW - Adolescence
KW - Psychopathology
KW - Neurodevelopment
KW - Neuroimaging
KW - Environment
KW - ABCD study
KW - Adolescence
KW - Psychopathology
KW - Neurodevelopment
KW - Neuroimaging
KW - Environment
UR - http://hdl.handle.net/10807/305458
U2 - 10.1016/j.biopsych.2020.08.014
DO - 10.1016/j.biopsych.2020.08.014
M3 - Article
SN - 1873-2402
VL - 89
SP - 510
EP - 520
JO - Biological Psychiatry
JF - Biological Psychiatry
ER -