TY - JOUR
T1 - Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation
AU - Tecchio, F
AU - Cancelli, A
AU - Cottone, C
AU - Zito, G
AU - Pasqualetti, P
AU - Ghazaryan, A
AU - Rossini, Paolo Maria
AU - Filippi, Mm
PY - 2014
Y1 - 2014
N2 - Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
AB - Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
KW - multiple sclerosis
KW - sclerosis
KW - multiple sclerosis
KW - sclerosis
UR - https://publicatt.unicatt.it/handle/10807/63948
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84906098473&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84906098473&origin=inward
U2 - 10.1007/s00415-014-7377-9
DO - 10.1007/s00415-014-7377-9
M3 - Article
SN - 0340-5354
VL - 261
SP - 1552
EP - 1558
JO - Journal of Neurology
JF - Journal of Neurology
IS - 8
ER -