TY - JOUR
T1 - Multiple sclerosis attacks triggered by hyperprolactinemia
AU - Nociti, Viviana
AU - Frisullo, Giovanni
AU - Tartaglione, Tommaso
AU - Patanella, Agata Katia
AU - Iorio, Raffaele
AU - Tonali, Pietro Attilio
AU - Batocchi, Anna Paola
PY - 2009
Y1 - 2009
N2 - Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course
AB - Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course
KW - hyperprolactinemia
KW - multiple sclerosis
KW - hyperprolactinemia
KW - multiple sclerosis
UR - http://hdl.handle.net/10807/19703
M3 - Article
SN - 0167-594X
SP - 407
EP - 409
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
ER -