Multicentre registry of brain-injured patients with disorder of consciousness: Rationale and preliminary data

Angelo Pascarella, Salvatore Fiorenza, Orsola Masotta, Valentina Tibollo, Danila Vella, Antonio Nardone, Maria Rossi, Paolo Volanti, Francesca Madonia, Gioacchino Castronovo, Domenico De Cicco, Caterina Guarnaschelli, Maria Pia Achilli, Concetta Chiapparino, Maria Teresa Angelillo, Maria Antonietta Tommasi, Fabrizio Pisano, Giuseppe Grioni, Giuliana Vezzadini, Giorgio FerrieroStefano Salvaderi, Riccardo Bellazzi, Anna Estraneo*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

4 Citazioni (Scopus)


Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On the basis of this consideration, we devised a multicentre prospective registry for patients with DoC admitted to ten intensive rehabilitation units. The registry collects homogeneous and detailed data on patients’ demographic and clinical features, neurophysiological and neuroimaging findings, and medical and surgical complications. Here we present the rationale and the design of the registry and the preliminary results obtained in 53 patients with DoC (vegetative state or minimally conscious state) enrolled during the first seven months of the study. Data at 6-month post-injury follow-up were available for 46 of them. This registry could be an important tool for collecting high-quality data through the application of rigorous methods, and it could be used in the routine management of patients with DoC admitted to rehabilitation settings.
Lingua originaleEnglish
pagine (da-a)19-30
Numero di pagine12
RivistaFunctional Neurology
Stato di pubblicazionePubblicato - 2018
Pubblicato esternamente


  • Disorders of consciousness
  • Minimally conscious state
  • Neurorehabilitation
  • Outcome
  • Registry
  • Vegetative state


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