Multicenter evaluation of an enzymatic method for glycated albumin

Renata Paleari; Graziella Bonetti; Cinzia Anna Maria Calla'; Mariarosa Carta; Ferruccio Ceriotti; Nicola Di Gaetano; Marilisa Ferri; Elena Guerra; Gabriella Lavalle; Claudia Lo Cascio; Francesca Gabriela Martino; Martina Montagnana; Marco Moretti; Gabriele Santini; Donata Scribano; Roberto Testa; Anna Vero; Andrea Mosca

doi:10.1016/j.cca.2017.03.028

Multicenter evaluation of an enzymatic method for glycated albumin

Renata Paleari, Graziella Bonetti, Cinzia Anna Maria Calla', Mariarosa Carta, Ferruccio Ceriotti, Nicola Di Gaetano, Marilisa Ferri, Elena Guerra, Gabriella Lavalle, Claudia Lo Cascio, Francesca Gabriela Martino, Martina Montagnana, Marco Moretti, Gabriele Santini, Donata Scribano, Roberto Testa, Anna Vero, Andrea Mosca

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

9 Citazioni (Scopus)

Abstract

BACKGROUND: The use of glycated albumin (GA) has been proposed as an additional glycemic control marker particularly useful in intermediate-term monitoring and in situation when HbA1c test is not reliable. METHODS: We have performed the first multicenter evaluation of the analytical performance of the enzymatic method quantILab Glycated Albumin assay implemented on the most widely used clinical chemistry analyzers (i.e. Abbott Architect C8000, Beckman Coulter AU 480 and 680, Roche Cobas C6000, Siemens ADVIA 2400 and 2400 XPT). RESULTS: The repeatability of the GA measurement (expressed as CV, %) implemented in the participating centers ranged between 0.9% and 1.2%. The within-laboratory CVs ranged between 1.2% and 1.6%. A good alignment between laboratories was found, with correlation coefficients from 0.996 to 0.998. Linearity was confirmed in the range from 7.6 to 84.7%. CONCLUSION: The new enzymatic method for glycated albumin evaluated by our investigation is suitable for clinical use.

Lingua originale	English
pagine (da-a)	81-86
Numero di pagine	6
Rivista	Clinica Chimica Acta
Volume	2017
DOI	https://doi.org/10.1016/j.cca.2017.03.028
Stato di pubblicazione	Pubblicato - 2017

Keywords

Glicated Albumin
Multicenter evaluation
diabetes

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1016/j.cca.2017.03.028

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Paleari, R., Bonetti, G., Calla', C. A. M., Carta, M., Ceriotti, F., Di Gaetano, N., Ferri, M., Guerra, E., Lavalle, G., Cascio, C. L., Martino, F. G., Montagnana, M., Moretti, M., Santini, G., Scribano, D., Testa, R., Vero, A., & Mosca, A. (2017). Multicenter evaluation of an enzymatic method for glycated albumin. Clinica Chimica Acta, 2017, 81-86. https://doi.org/10.1016/j.cca.2017.03.028

@article{d923d4f44aed4214b48e55499e76c160,

title = "Multicenter evaluation of an enzymatic method for glycated albumin",

abstract = "BACKGROUND: The use of glycated albumin (GA) has been proposed as an additional glycemic control marker particularly useful in intermediate-term monitoring and in situation when HbA1c test is not reliable. METHODS: We have performed the first multicenter evaluation of the analytical performance of the enzymatic method quantILab Glycated Albumin assay implemented on the most widely used clinical chemistry analyzers (i.e. Abbott Architect C8000, Beckman Coulter AU 480 and 680, Roche Cobas C6000, Siemens ADVIA 2400 and 2400 XPT). RESULTS: The repeatability of the GA measurement (expressed as CV, %) implemented in the participating centers ranged between 0.9% and 1.2%. The within-laboratory CVs ranged between 1.2% and 1.6%. A good alignment between laboratories was found, with correlation coefficients from 0.996 to 0.998. Linearity was confirmed in the range from 7.6 to 84.7%. CONCLUSION: The new enzymatic method for glycated albumin evaluated by our investigation is suitable for clinical use.",

keywords = "Glicated Albumin, Multicenter evaluation, diabetes, Glicated Albumin, Multicenter evaluation, diabetes",

author = "Renata Paleari and Graziella Bonetti and Calla', {Cinzia Anna Maria} and Mariarosa Carta and Ferruccio Ceriotti and {Di Gaetano}, Nicola and Marilisa Ferri and Elena Guerra and Gabriella Lavalle and Cascio, {Claudia Lo} and Martino, {Francesca Gabriela} and Martina Montagnana and Marco Moretti and Gabriele Santini and Donata Scribano and Roberto Testa and Anna Vero and Andrea Mosca",

year = "2017",

doi = "10.1016/j.cca.2017.03.028",

language = "English",

volume = "2017",

pages = "81--86",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier B.V.",

}

Paleari, R, Bonetti, G, Calla', CAM, Carta, M, Ceriotti, F, Di Gaetano, N, Ferri, M, Guerra, E, Lavalle, G, Cascio, CL, Martino, FG, Montagnana, M, Moretti, M, Santini, G, Scribano, D, Testa, R, Vero, A & Mosca, A 2017, 'Multicenter evaluation of an enzymatic method for glycated albumin', Clinica Chimica Acta, vol. 2017, pagg. 81-86. https://doi.org/10.1016/j.cca.2017.03.028

TY - JOUR

T1 - Multicenter evaluation of an enzymatic method for glycated albumin

AU - Paleari, Renata

AU - Bonetti, Graziella

AU - Calla', Cinzia Anna Maria

AU - Carta, Mariarosa

AU - Ceriotti, Ferruccio

AU - Di Gaetano, Nicola

AU - Ferri, Marilisa

AU - Guerra, Elena

AU - Lavalle, Gabriella

AU - Cascio, Claudia Lo

AU - Martino, Francesca Gabriela

AU - Montagnana, Martina

AU - Moretti, Marco

AU - Santini, Gabriele

AU - Scribano, Donata

AU - Testa, Roberto

AU - Vero, Anna

AU - Mosca, Andrea

PY - 2017

Y1 - 2017

N2 - BACKGROUND: The use of glycated albumin (GA) has been proposed as an additional glycemic control marker particularly useful in intermediate-term monitoring and in situation when HbA1c test is not reliable. METHODS: We have performed the first multicenter evaluation of the analytical performance of the enzymatic method quantILab Glycated Albumin assay implemented on the most widely used clinical chemistry analyzers (i.e. Abbott Architect C8000, Beckman Coulter AU 480 and 680, Roche Cobas C6000, Siemens ADVIA 2400 and 2400 XPT). RESULTS: The repeatability of the GA measurement (expressed as CV, %) implemented in the participating centers ranged between 0.9% and 1.2%. The within-laboratory CVs ranged between 1.2% and 1.6%. A good alignment between laboratories was found, with correlation coefficients from 0.996 to 0.998. Linearity was confirmed in the range from 7.6 to 84.7%. CONCLUSION: The new enzymatic method for glycated albumin evaluated by our investigation is suitable for clinical use.

AB - BACKGROUND: The use of glycated albumin (GA) has been proposed as an additional glycemic control marker particularly useful in intermediate-term monitoring and in situation when HbA1c test is not reliable. METHODS: We have performed the first multicenter evaluation of the analytical performance of the enzymatic method quantILab Glycated Albumin assay implemented on the most widely used clinical chemistry analyzers (i.e. Abbott Architect C8000, Beckman Coulter AU 480 and 680, Roche Cobas C6000, Siemens ADVIA 2400 and 2400 XPT). RESULTS: The repeatability of the GA measurement (expressed as CV, %) implemented in the participating centers ranged between 0.9% and 1.2%. The within-laboratory CVs ranged between 1.2% and 1.6%. A good alignment between laboratories was found, with correlation coefficients from 0.996 to 0.998. Linearity was confirmed in the range from 7.6 to 84.7%. CONCLUSION: The new enzymatic method for glycated albumin evaluated by our investigation is suitable for clinical use.

KW - Glicated Albumin

KW - Multicenter evaluation

KW - diabetes

KW - Glicated Albumin

KW - Multicenter evaluation

KW - diabetes

UR - http://hdl.handle.net/10807/107261

U2 - 10.1016/j.cca.2017.03.028

DO - 10.1016/j.cca.2017.03.028

M3 - Article

SN - 0009-8981

VL - 2017

SP - 81

EP - 86

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

Multicenter evaluation of an enzymatic method for glycated albumin

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo