Multicenter evaluation of an enzymatic method for glycated albumin

Cinzia Anna Maria Calla', Donata Scribano, Renata Paleari, Graziella Bonetti, Mariarosa Carta, Ferruccio Ceriotti, Nicola Di Gaetano, Marilisa Ferri, Elena Guerra, Gabriella Lavalle, Claudia Lo Cascio, Francesca Gabriela Martino, Martina Montagnana, Marco Moretti, Gabriele Santini, Roberto Testa, Anna Vero, Andrea Mosca

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

8 Citazioni (Scopus)

Abstract

BACKGROUND: The use of glycated albumin (GA) has been proposed as an additional glycemic control marker particularly useful in intermediate-term monitoring and in situation when HbA1c test is not reliable. METHODS: We have performed the first multicenter evaluation of the analytical performance of the enzymatic method quantILab Glycated Albumin assay implemented on the most widely used clinical chemistry analyzers (i.e. Abbott Architect C8000, Beckman Coulter AU 480 and 680, Roche Cobas C6000, Siemens ADVIA 2400 and 2400 XPT). RESULTS: The repeatability of the GA measurement (expressed as CV, %) implemented in the participating centers ranged between 0.9% and 1.2%. The within-laboratory CVs ranged between 1.2% and 1.6%. A good alignment between laboratories was found, with correlation coefficients from 0.996 to 0.998. Linearity was confirmed in the range from 7.6 to 84.7%. CONCLUSION: The new enzymatic method for glycated albumin evaluated by our investigation is suitable for clinical use.
Lingua originaleEnglish
pagine (da-a)81-86
Numero di pagine6
RivistaClinica Chimica Acta
Volume2017
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Glicated Albumin
  • Multicenter evaluation
  • diabetes

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