Abstract
Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.
Lingua originale | English |
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pagine (da-a) | 1975-1979 |
Numero di pagine | 5 |
Rivista | The Lancet |
Volume | 356 |
Stato di pubblicazione | Pubblicato - 2000 |
Pubblicato esternamente | Sì |
Keywords
- Brain
- Brain Tissue Transplantation
- Cognition
- Corpus Striatum
- Evoked Potentials, Somatosensory
- Follow-Up Studies
- Humans
- Huntington Disease
- Magnetic Resonance Imaging
- Motor Activity
- Neuropsychological Tests
- Tomography, Emission-Computed
- Treatment Outcome