@article{3191467501b9404996a5e694708ae98d,
title = "Motor and cognitive improvements in patients with Huntington's disease after neural transplantation",
abstract = "Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.",
keywords = "Brain, Brain Tissue Transplantation, Cognition, Corpus Striatum, Evoked Potentials, Somatosensory, Follow-Up Studies, Humans, Huntington Disease, Magnetic Resonance Imaging, Motor Activity, Neuropsychological Tests, Tomography, Emission-Computed, Treatment Outcome, Brain, Brain Tissue Transplantation, Cognition, Corpus Striatum, Evoked Potentials, Somatosensory, Follow-Up Studies, Humans, Huntington Disease, Magnetic Resonance Imaging, Motor Activity, Neuropsychological Tests, Tomography, Emission-Computed, Treatment Outcome",
author = "Paolo Bartolomeo and {Dalla Barba}, Gianfranco and {Bachoud L{\'e}vi}, Ac and P R{\'e}my and Jp Nguyen and P Brugi{\`e}res and Jp Lefaucheur and C Bourdet and S Baudic and V Gaura and P Maison and B Haddad and Mf Boiss{\'e} and T Grandmougin and R J{\'e}ny and Jd Degos and F Lisovoski and Am Ergis and E Pailhous and Pierre Cesaro and P Hantraye and M. Peschanski",
year = "2000",
language = "English",
volume = "356",
pages = "1975--1979",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Lancet Limited:42 Bedford Square, London WC1B 3SL United Kingdom:011 44 207 4364981, EMAIL: custserv@lancet.com, INTERNET: http://www.thelancet.com, Fax: 011 44 207 3236433",
}