Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

Ac Bachoud Lévi; P Rémy; Jp Nguyen; P Brugières; Jp Lefaucheur; C Bourdet; S Baudic; V Gaura; P Maison; B Haddad; Mf Boissé; T Grandmougin; R Jény; Paolo Bartolomeo; Gianfranco Dalla Barba; Jd Degos; F Lisovoski; Am Ergis; E Pailhous; Pierre Cesaro; P Hantraye; M. Peschanski

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

Ac Bachoud Lévi, P Rémy, Jp Nguyen, P Brugières, Jp Lefaucheur, C Bourdet, S Baudic, V Gaura, P Maison, B Haddad, Mf Boissé, T Grandmougin, R Jény, Paolo Bartolomeo, Gianfranco Dalla Barba, Jd Degos, F Lisovoski, Am Ergis, E Pailhous, Pierre CesaroP Hantraye, M. Peschanski

Risultato della ricerca: Contributo in rivista › Articolo in rivista

379 Citazioni (Scopus)

Abstract

Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.

Lingua originale	English
pagine (da-a)	1975-1979
Numero di pagine	5
Rivista	The Lancet
Volume	356
Stato di pubblicazione	Pubblicato - 2000
Pubblicato esternamente	Sì

Keywords

Brain
Brain Tissue Transplantation
Cognition
Corpus Striatum
Evoked Potentials, Somatosensory
Follow-Up Studies
Humans
Huntington Disease
Magnetic Resonance Imaging
Motor Activity
Neuropsychological Tests
Tomography, Emission-Computed
Treatment Outcome

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Bachoud Lévi, A., Rémy, P., Nguyen, J., Brugières, P., Lefaucheur, J., Bourdet, C., Baudic, S., Gaura, V., Maison, P., Haddad, B., Boissé, M., Grandmougin, T., Jény, R., Bartolomeo, P., Dalla Barba, G., Degos, J., Lisovoski, F., Ergis, A., Pailhous, E., ... Peschanski, M. (2000). Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. The Lancet, 356, 1975-1979.

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title = "Motor and cognitive improvements in patients with Huntington's disease after neural transplantation",

abstract = "Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.",

keywords = "Brain, Brain Tissue Transplantation, Cognition, Corpus Striatum, Evoked Potentials, Somatosensory, Follow-Up Studies, Humans, Huntington Disease, Magnetic Resonance Imaging, Motor Activity, Neuropsychological Tests, Tomography, Emission-Computed, Treatment Outcome, Brain, Brain Tissue Transplantation, Cognition, Corpus Striatum, Evoked Potentials, Somatosensory, Follow-Up Studies, Humans, Huntington Disease, Magnetic Resonance Imaging, Motor Activity, Neuropsychological Tests, Tomography, Emission-Computed, Treatment Outcome",

author = "{Bachoud L{\'e}vi}, Ac and P R{\'e}my and Jp Nguyen and P Brugi{\`e}res and Jp Lefaucheur and C Bourdet and S Baudic and V Gaura and P Maison and B Haddad and Mf Boiss{\'e} and T Grandmougin and R J{\'e}ny and Paolo Bartolomeo and {Dalla Barba}, Gianfranco and Jd Degos and F Lisovoski and Am Ergis and E Pailhous and Pierre Cesaro and P Hantraye and M. Peschanski",

year = "2000",

language = "English",

volume = "356",

pages = "1975--1979",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Lancet Limited:42 Bedford Square, London WC1B 3SL United Kingdom:011 44 207 4364981, EMAIL: custserv@lancet.com, INTERNET: http://www.thelancet.com, Fax: 011 44 207 3236433",

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Bachoud Lévi, A, Rémy, P, Nguyen, J, Brugières, P, Lefaucheur, J, Bourdet, C, Baudic, S, Gaura, V, Maison, P, Haddad, B, Boissé, M, Grandmougin, T, Jény, R, Bartolomeo, P, Dalla Barba, G, Degos, J, Lisovoski, F, Ergis, A, Pailhous, E, Cesaro, P, Hantraye, P & Peschanski, M 2000, 'Motor and cognitive improvements in patients with Huntington's disease after neural transplantation', The Lancet, vol. 356, pagg. 1975-1979.

TY - JOUR

T1 - Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

AU - Bachoud Lévi, Ac

AU - Rémy, P

AU - Nguyen, Jp

AU - Brugières, P

AU - Lefaucheur, Jp

AU - Bourdet, C

AU - Baudic, S

AU - Gaura, V

AU - Maison, P

AU - Haddad, B

AU - Boissé, Mf

AU - Grandmougin, T

AU - Jény, R

AU - Bartolomeo, Paolo

AU - Dalla Barba, Gianfranco

AU - Degos, Jd

AU - Lisovoski, F

AU - Ergis, Am

AU - Pailhous, E

AU - Cesaro, Pierre

AU - Hantraye, P

AU - Peschanski, M.

PY - 2000

Y1 - 2000

N2 - Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.

AB - Huntington's disease is a neurodegenerative disease of genetic origin that mainly affects the striatum. It has severe motor and cognitive consequences and, up to now, no treatment. Motor and cognitive functions can be restored in experimental animal models by means of intrastriatal transplantation of fetal striatal neuroblasts. We explored whether grafts of human fetal striatal tissue could survive and have detectable effects in five patients with mild to moderate Huntington's disease.

KW - Brain

KW - Brain Tissue Transplantation

KW - Cognition

KW - Corpus Striatum

KW - Evoked Potentials, Somatosensory

KW - Follow-Up Studies

KW - Humans

KW - Huntington Disease

KW - Magnetic Resonance Imaging

KW - Motor Activity

KW - Neuropsychological Tests

KW - Tomography, Emission-Computed

KW - Treatment Outcome

KW - Brain

KW - Brain Tissue Transplantation

KW - Cognition

KW - Corpus Striatum

KW - Evoked Potentials, Somatosensory

KW - Follow-Up Studies

KW - Humans

KW - Huntington Disease

KW - Magnetic Resonance Imaging

KW - Motor Activity

KW - Neuropsychological Tests

KW - Tomography, Emission-Computed

KW - Treatment Outcome

UR - http://hdl.handle.net/10807/20130

M3 - Article

SN - 0140-6736

VL - 356

SP - 1975

EP - 1979

JO - The Lancet

JF - The Lancet

ER -

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

Abstract

Keywords

OSS delle Nazioni Unite

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