Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules

Maurizio Martini, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Luigi Maria Larocca, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Guido Fadda

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.
Lingua originaleEnglish
pagine (da-a)1-36
Numero di pagine36
RivistaCytopathology
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • BRAF mutation
  • immunocytochemistry
  • molecular testing
  • plump cells
  • thyroid malignancies
  • thyroid nodules

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