Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules

E. D. Rossi; Maurizio Martini; Sara Capodimonti; Tonia Cenci; Mirna Bilotta; Francesco Pierconti; Alfredo Pontecorvi; Celestino Pio Lombardi; Guido Fadda; Luigi Maria Larocca

doi:10.1111/cyt.12555

Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules

E. D. Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Luigi Maria Larocca

Risultato della ricerca: Contributo in rivista › Articolo in rivista

8 Citazioni (Scopus)

Abstract

Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.

Lingua originale	English
pagine (da-a)	1-36
Numero di pagine	36
Rivista	Cytopathology
DOI	https://doi.org/10.1111/cyt.12555
Stato di pubblicazione	Pubblicato - 2018

Keywords

BRAF mutation
immunocytochemistry
molecular testing
plump cells
thyroid malignancies
thyroid nodules

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10.1111/cyt.12555

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title = "Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules",

abstract = "Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.",

keywords = "BRAF mutation, immunocytochemistry, molecular testing, plump cells, thyroid malignancies, thyroid nodules, BRAF mutation, immunocytochemistry, molecular testing, plump cells, thyroid malignancies, thyroid nodules",

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doi = "10.1111/cyt.12555",

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T1 - Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules

AU - Rossi, E. D.

AU - Martini, Maurizio

AU - Capodimonti, Sara

AU - Cenci, Tonia

AU - Bilotta, Mirna

AU - Pierconti, Francesco

AU - Pontecorvi, Alfredo

AU - Lombardi, Celestino Pio

AU - Fadda, Guido

AU - Larocca, Luigi Maria

PY - 2018

Y1 - 2018

N2 - Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.

AB - Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV600E ), miRNA analysis is proposed for FNs. This study discusses the validation of a diagnostic algorithm in FN with a special focus on the role of morphology then followed by AT.

KW - BRAF mutation

KW - immunocytochemistry

KW - molecular testing

KW - plump cells

KW - thyroid malignancies

KW - thyroid nodules

KW - BRAF mutation

KW - immunocytochemistry

KW - molecular testing

KW - plump cells

KW - thyroid malignancies

KW - thyroid nodules

UR - http://hdl.handle.net/10807/120352

U2 - 10.1111/cyt.12555

DO - 10.1111/cyt.12555

M3 - Article

SN - 0956-5507

SP - 1

EP - 36

JO - Cytopathology

JF - Cytopathology

ER -

Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules

Abstract

Keywords

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