TY - JOUR
T1 - Morphology and immunophenotyping issues in the integrated diagnosis of hematologic disorders of elderly patients
AU - Zini Tanzi, Gina
AU - Béné, Marie C.
PY - 2014
Y1 - 2014
N2 - In the middle of the 19th century, when Bennett and Virchow were trying to decide whether “leucocythemia” or “leukemia” would be the proper word to describe the recently discovered chronic myelogenous leukemia (CML), life expectancy was steadily rising from around 40 years of age in the previous century, to finally reach 50 years in 1900. This is to say that many hematologic disorders were extremely rare at that time. Nowadays, a newborn baby may expect to live up to 100 years old.1 Among the myriad of challenges this perspective raises, that of an increase in chronic hematologic disorders is to be foreseen and in fact can already be perceived. Four major evolutions can be highlighted which will require the skill of trained morphologists and adapted flow cytometry studies, for integrated diagnoses and follow up, where cytogenetics has already an important place and where that of molecular and next generation sequencing (NGS) techniques will certainly find theirs. They are namely: i) nutritional deficiency-related and autoimmune disorders, mostly anemia;2 ii) chronic myeloproliferative/myelodysplastic or lymphoid neoplasms; iii) therapy-related secondary leukemia/lymphomas; and iv) follow up of long-term survivors.
AB - In the middle of the 19th century, when Bennett and Virchow were trying to decide whether “leucocythemia” or “leukemia” would be the proper word to describe the recently discovered chronic myelogenous leukemia (CML), life expectancy was steadily rising from around 40 years of age in the previous century, to finally reach 50 years in 1900. This is to say that many hematologic disorders were extremely rare at that time. Nowadays, a newborn baby may expect to live up to 100 years old.1 Among the myriad of challenges this perspective raises, that of an increase in chronic hematologic disorders is to be foreseen and in fact can already be perceived. Four major evolutions can be highlighted which will require the skill of trained morphologists and adapted flow cytometry studies, for integrated diagnoses and follow up, where cytogenetics has already an important place and where that of molecular and next generation sequencing (NGS) techniques will certainly find theirs. They are namely: i) nutritional deficiency-related and autoimmune disorders, mostly anemia;2 ii) chronic myeloproliferative/myelodysplastic or lymphoid neoplasms; iii) therapy-related secondary leukemia/lymphomas; and iv) follow up of long-term survivors.
KW - hematologic disorders of elderly patients
KW - hematologic disorders of elderly patients
UR - http://hdl.handle.net/10807/63613
UR - http://dx.medra.org/10.3324/haematol.2014.106724
U2 - 10.3324/haematol.2014.106724
DO - 10.3324/haematol.2014.106724
M3 - Article
SN - 0390-6078
VL - 99
SP - 951
EP - 953
JO - Haematologica
JF - Haematologica
ER -