Morpho-functional modifications of human neutrophils induced by aqueous cigarette smoke extract: comparison with chemiluminescence activity.

Federica Iavarone, Silvia Persichilli, Bruno Zappacosta, Giuseppe Ettore Martorana, Stefano Papini, Jacopo Gervasoni, Silvia Fasanella, Bruno Giardina, Pasquale De Sole

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Cigarette smoking plays an important role as a cause of morbidity and mortality in humans, involving respiratory, cardiovascular, digestive and reproductive systems. Tobacco smoke contains a large number of molecules, some of which are proven carcinogens. Although not fully understood, polymorphonuclear leukocytes seem to play a crucial role in the mechanisms by which tobacco smoke compounds are implicated in smoke-related diseases. In this paper the effects of an aqueous cigarette smoke extract on the expression of adhesion molecules of polymorphonuclear leukocytes together with the changes in the cell morphology have been related to the chemiluminescence activity. The results obtained show that polymorphonuclear leukocytes treated with aqueous cigarette smoke extract are significantly impaired, as suggested by the changes of chemiluminescence activity, of membrane receptors (CD18, CD62), myeloperoxidase expression and of cell morphology. Altogether the present data indicate that treated polymorphonuclear leukocytes are ineffectively activated and therefore unable to phagocytize zymosan particles
Lingua originaleEnglish
pagine (da-a)331-335
Numero di pagine4
RivistaLuminescence
Volume2010
Stato di pubblicazionePubblicato - 2010

Keywords

  • integrins
  • leukocytes
  • smoke

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