Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians.

Roberto Pola*, Andrea Flex, Eleonora Gaetani, Anna Silvia Proia, Pierangelo Papaleo, Angela Di Giorgio, Giuseppe Straface, Giovanni Pecorini, Michele Lorenzo Serricchio, Paolo Pola

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolopeer review

41 Citazioni (Scopus)

Abstract

Monocyte chemoattractant protein-1 (MCP-1) is a key molecule for monocyte chemotaxis and tissue extravasation and for the modulation of leukocyte function during inflammation. Upregulation of MCP-1 may occur in the brain of subjects affected by Alzheimer's disease (AD) and MCP-1 levels in plasma and cerebrospinal fluid have been proposed as biological markers for the inflammatory process that accompanies AD pathogenesis. Importantly, serum levels and biological activity of MCP-1 protein are strongly influenced by a single nucleotide polymorphism occurring at position -2518 of the MCP-1 gene promoter. A recent study has investigated the possible association between this gene polymorphism and AD in a Spanish population, with negative results. Here, we performed a case-control study to test whether the risk for AD might be influenced by the -2518 A/G polymorphism of the MCP-1 gene in an ethnically homogeneous Italian population. The GG genotype and the G allele of the MCP-1 gene polymorphism were significantly more common in the AD group than in control individuals (P<0.0001) A logistic regression analysis indicated that the GG genotype was an independent risk factor for AD in our population. This effect was not influenced by the presence of the APOE 4 high-risk allele, nor by the presence of other gene variations associated with a pro-inflammatory phenotype. These findings indicate that the -2518 A/G polymorphism of the MCP-1 gene is associated with AD in Italians and confirm that inflammatory gene variations may be important contributors in the development and progression of neurodegenerative disorders.
Lingua originaleInglese
pagine (da-a)1249-1252
Numero di pagine4
RivistaExperimental Gerontology
Numero di pubblicazione39(8)
DOI
Stato di pubblicazionePubblicato - 2004

All Science Journal Classification (ASJC) codes

  • Biochimica
  • Invecchiamento
  • Biologia Molecolare
  • Genetica
  • Endocrinologia
  • Biologia Cellulare

Keywords

  • MCP-1
  • alzheimer
  • gene polymorphism
  • inflammation

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