Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

A. Corbingi; I. Innocenti; A. Tomasso; R. Pasquale; A. Visentin; M. Varettoni; E. Flospergher; F. Autore; F. Morelli; L. Trentin; G. Reda; D. G. Efremov; Luca Laurenti

doi:10.1111/bjh.16975

Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

A. Corbingi
, I. Innocenti
, A. Tomasso
, R. Pasquale
, A. Visentin
, M. Varettoni
, E. Flospergher
, F. Autore
, F. Morelli
, L. Trentin
, G. Reda
, D. G. Efremov
, Luca Laurenti^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

2 Citazioni (Scopus)

Abstract

The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

Lingua originale	Inglese
pagine (da-a)	901-908
Numero di pagine	8
Rivista	British Journal of Haematology
Volume	190
Numero di pubblicazione	6
DOI	https://doi.org/10.1111/bjh.16975
Stato di pubblicazione	Pubblicato - 2020

OSS delle Nazioni Unite

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SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Ematologia

Keywords

80 and over
Adult
Aged
B-Cell
Chromosome Deletion
Chromosomes
Chronic
Disease-Free Survival
Female
Follow-Up Studies
Human
Humans
Immunoglobulin G
Immunoglobulin M
Leukemia
Lymphocytic
Male
Middle Aged
Neoplasm Proteins
Pair 12
Pair 17
Paraproteinemias
Retrospective Studies
Smith-Magenis Syndrome
Survival Rate
Trisomy
Tumor Suppressor Protein p53
chronic lymphocytic leukemia
gamma globulin
monoclonal gammopathy

Accesso al documento

10.1111/bjh.16975

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Corbingi, A., Innocenti, I., Tomasso, A., Pasquale, R., Visentin, A., Varettoni, M., Flospergher, E., Autore, F., Morelli, F., Trentin, L., Reda, G., Efremov, D. G., & Laurenti, L. (2020). Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia. British Journal of Haematology, 190(6), 901-908. https://doi.org/10.1111/bjh.16975

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title = "Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia",

abstract = "The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8\%), 149 (10\%), 200 (13·2\%) and 1083 (72\%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.",

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author = "A. Corbingi and I. Innocenti and A. Tomasso and R. Pasquale and A. Visentin and M. Varettoni and E. Flospergher and F. Autore and F. Morelli and L. Trentin and G. Reda and Efremov, \{D. G.\} and Luca Laurenti",

year = "2020",

doi = "10.1111/bjh.16975",

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Corbingi, A, Innocenti, I, Tomasso, A, Pasquale, R, Visentin, A, Varettoni, M, Flospergher, E, Autore, F, Morelli, F, Trentin, L, Reda, G, Efremov, DG & Laurenti, L 2020, 'Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia', British Journal of Haematology, vol. 190, n. 6, pagg. 901-908. https://doi.org/10.1111/bjh.16975

TY - JOUR

T1 - Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

AU - Corbingi, A.

AU - Innocenti, I.

AU - Tomasso, A.

AU - Pasquale, R.

AU - Visentin, A.

AU - Varettoni, M.

AU - Flospergher, E.

AU - Autore, F.

AU - Morelli, F.

AU - Trentin, L.

AU - Reda, G.

AU - Efremov, D. G.

AU - Laurenti, Luca

PY - 2020

Y1 - 2020

N2 - The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

AB - The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

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KW - Adult

KW - Aged

KW - B-Cell

KW - Chromosome Deletion

KW - Chromosomes

KW - Chronic

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Human

KW - Humans

KW - Immunoglobulin G

KW - Immunoglobulin M

KW - Leukemia

KW - Lymphocytic

KW - Male

KW - Middle Aged

KW - Neoplasm Proteins

KW - Pair 12

KW - Pair 17

KW - Paraproteinemias

KW - Retrospective Studies

KW - Smith-Magenis Syndrome

KW - Survival Rate

KW - Trisomy

KW - Tumor Suppressor Protein p53

KW - chronic lymphocytic leukemia

KW - gamma globulin

KW - monoclonal gammopathy

KW - 80 and over

KW - Adult

KW - Aged

KW - B-Cell

KW - Chromosome Deletion

KW - Chromosomes

KW - Chronic

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Human

KW - Humans

KW - Immunoglobulin G

KW - Immunoglobulin M

KW - Leukemia

KW - Lymphocytic

KW - Male

KW - Middle Aged

KW - Neoplasm Proteins

KW - Pair 12

KW - Pair 17

KW - Paraproteinemias

KW - Retrospective Studies

KW - Smith-Magenis Syndrome

KW - Survival Rate

KW - Trisomy

KW - Tumor Suppressor Protein p53

KW - chronic lymphocytic leukemia

KW - gamma globulin

KW - monoclonal gammopathy

UR - https://publicatt.unicatt.it/handle/10807/179621

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U2 - 10.1111/bjh.16975

DO - 10.1111/bjh.16975

M3 - Article

SN - 0007-1048

VL - 190

SP - 901

EP - 908

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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