Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

Andrea Corbingi, Idanna Innocenti, Annamaria Tomasso, Raffaella Pasquale, Andrea Visentin, Marzia Varettoni, Elena Flospergher, Francesco Autore, Francesca Morelli, Livio Trentin, Gianluigi Reda, Dimitar G. Efremov, Luca Laurenti*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)


The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.
Lingua originaleEnglish
pagine (da-a)901-908
Numero di pagine8
RivistaBritish Journal of Haematology
Stato di pubblicazionePubblicato - 2020


  • Adult
  • Aged, 80 and over
  • Chromosome Deletion
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 17
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G
  • Immunoglobulin M
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Male
  • Middle Aged
  • Neoplasm Proteins
  • Paraproteinemias
  • Retrospective Studies
  • Smith-Magenis Syndrome
  • Survival Rate
  • Trisomy
  • Tumor Suppressor Protein p53
  • chronic lymphocytic leukemia
  • gamma globulin
  • monoclonal gammopathy


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