Molecular typing of Mycobacterium tuberculosis strains: A fundamental tool for tuberculosis control and elimination

Giovanni Delogu, Angela Cannas, Antonio Mazzarelli, Antonino Di Caro, Enrico Girardi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Tuberculosis (TB) is still an important cause of morbidity and mortality worldwide. An improvement of the strategies for disease control is necessary in both low- and high-incidence TB countries. Clinicians, epidemiologists, laboratory specialists, and public health players should work together in order to achieve a significant reduction in TB transmission and spread of drug-resistant strains. Effective TB surveillance relies on early diagnosis of new cases, appropriate therapy, and accurate detection of outbreaks in the community, in order to implement proper TB control strategies. To achieve this goal, information from classical and molecular epidemiology, together with patient clinical data need to be combined. In this review, we summarize the methodologies currently used in molecular epidemiology, namely molecular typing. We will discuss their efficiency to phylogenetically characterize Mycobacterium tuberculosis isolates, and their ability to provide information that can be useful for disease control. We will also introduce next generation sequencing as the methodology that potentially could provide in a short time both, detection of new outbreaks and identification of resistance patterns. This could envision a potential of next generation sequencing as an important tool for accurate patient management and disease control.
Lingua originaleEnglish
pagine (da-a)38-42
Numero di pagine5
RivistaInfectious Disease Reports
Volume8
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Infectious Diseases
  • Molecular typing
  • Multidrug resistance
  • Outbreak investigation
  • Tuberculosis
  • Whole genome sequencing

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