TY - JOUR
T1 - Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling
AU - Fetoni, Anna Rita
AU - Paciello, Fabiola
AU - Mezzogori, Daniele
AU - Rolesi, Rolando
AU - Eramo, Sara Letizia Maria
AU - Paludetti, Gaetano
AU - Troiani, Diana
PY - 2015
Y1 - 2015
N2 - In oncology, an emerging paradigm emphasises molecularly targeted approaches for cancer prevention and therapy and the use of adjuvant chemotherapeutics to overcome cisplatin limitations. Owing to their safe use, some polyphenols, such as curcumin, modulate important pathways or molecular targets in cancers. This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.
AB - In oncology, an emerging paradigm emphasises molecularly targeted approaches for cancer prevention and therapy and the use of adjuvant chemotherapeutics to overcome cisplatin limitations. Owing to their safe use, some polyphenols, such as curcumin, modulate important pathways or molecular targets in cancers. This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.
KW - cisplatin
KW - ototoxicity
KW - cisplatin
KW - ototoxicity
UR - https://publicatt.unicatt.it/handle/10807/70604
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84947484631&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84947484631&origin=inward
U2 - 10.1038/bjc.2015.359
DO - 10.1038/bjc.2015.359
M3 - Article
SN - 1532-1827
VL - 113
SP - 1434
EP - 1444
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 10
ER -