TY - JOUR
T1 - Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study
AU - Conter, Valentino
AU - Bartram, Claus R.
AU - Valsecchi, Maria Grazia
AU - Schrauder, André
AU - Panzer-Grümayer, Renate
AU - Möricke, Anja
AU - Aricò, Maurizio
AU - Zimmermann, Martin
AU - Mann, Georg
AU - De Rossi, Giulio
AU - Stanulla, Martin
AU - Locatelli, Franco
AU - Basso, Giuseppe
AU - Niggli, Felix
AU - Barisone, Elena
AU - Henze, Günter
AU - Ludwig, Wolf-Dieter
AU - Haas, Oskar A.
AU - Cazzaniga, Giovanni
AU - Koehler, Rolf
AU - Silvestri, Daniela
AU - Bradtke, Jutta
AU - Parasole, Rosanna
AU - Beier, Rita
AU - Van Dongen, Jacques J. M.
AU - Biondi, Andrea
AU - Schrappe, Martin
PY - 2010
Y1 - 2010
N2 - The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Munster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time introduced standardized quantitative assessment of minimal residual disease (MRD) based on immunoglobulin and T-cell receptor gene rearrangements as polymerase chain reaction targets (PCR-MRD), at 2 time points (TPs), to stratify patients in a large prospective study. Patients with precursor B (pB) ALL (n = 3184) were considered MRD standard risk (MRD-SR) if MRD was already negative at day 33 (analyzed by 2 markers, with a sensitivity of at least 10(-4)); MRD high risk (MRD-HR) if 10(-3) or more at day 78 and MRD intermediate risk (MRD-IR): others. MRD-SR patients were 42% (1348): 5-year event-free survival (EFS, standard error) is 92.3% (0.9). Fifty-two percent (1647) were MRD-IR: EFS 77.6% (1.3). Six percent of patients (189) were MRD-HR: EFS 50.1% (4.1; P < .001). PCR-MRD discriminated prognosis even on top of white blood cell count, age, early response to prednisone, and genotype. MRD response detected by sensitive quantitative PCR at 2 predefined TPs is highly predictive for relapse in childhood pB-ALL. The study is registered at http://clinicaltrials.gov: NCT00430118 for BFM and NCT00613457 for AIEOP. (Blood. 2010; 115(16): 3206-3214)
AB - The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Munster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time introduced standardized quantitative assessment of minimal residual disease (MRD) based on immunoglobulin and T-cell receptor gene rearrangements as polymerase chain reaction targets (PCR-MRD), at 2 time points (TPs), to stratify patients in a large prospective study. Patients with precursor B (pB) ALL (n = 3184) were considered MRD standard risk (MRD-SR) if MRD was already negative at day 33 (analyzed by 2 markers, with a sensitivity of at least 10(-4)); MRD high risk (MRD-HR) if 10(-3) or more at day 78 and MRD intermediate risk (MRD-IR): others. MRD-SR patients were 42% (1348): 5-year event-free survival (EFS, standard error) is 92.3% (0.9). Fifty-two percent (1647) were MRD-IR: EFS 77.6% (1.3). Six percent of patients (189) were MRD-HR: EFS 50.1% (4.1; P < .001). PCR-MRD discriminated prognosis even on top of white blood cell count, age, early response to prednisone, and genotype. MRD response detected by sensitive quantitative PCR at 2 predefined TPs is highly predictive for relapse in childhood pB-ALL. The study is registered at http://clinicaltrials.gov: NCT00430118 for BFM and NCT00613457 for AIEOP. (Blood. 2010; 115(16): 3206-3214)
KW - N/A
KW - N/A
UR - http://hdl.handle.net/10807/252375
U2 - 10.1182/blood-2009-10-248146
DO - 10.1182/blood-2009-10-248146
M3 - Article
SN - 1528-0020
VL - 115
SP - 3206
EP - 3214
JO - Blood
JF - Blood
ER -