Molecular insights into muscle homeostasis, atrophy and wasting

Bianca Maria Scicchitano, Gigliola Sica, Gabriella Dobrowolny, Antonio Musarò

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.
Lingua originaleEnglish
pagine (da-a)356-369
Numero di pagine14
RivistaCurrent Genomics
Volume19
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Anabolic pathways
  • Degradation of cell proteins
  • Genetics
  • Genetics (clinical)
  • Muscle atrophy
  • Muscle homeostasis
  • Muscle pathologies
  • Muscle wasting

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