Molecular detection of resistance to echinocandins

Brunella Posteraro, Maurizio Sanguinetti, Antonietta Vella, Elena De Carolis

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

In the last years, life-threatening fungal diseases have increased signifi cantly, due to the rising number of human individuals susceptible to fungal infections, which are in part complicated by the emergence of antifungal drug-resistant pathogens. Among yeasts, Candida albicans and Candida glabrata are the most common organisms responsible for invasive fungal diseases. The molecular detection of echinocandin resistance in Candida species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations. Here, we describe the current methods that enable researchers and/or clinical microbiologists to accurately detect echinocandin-resistant isolates of C. albicans and C. glabrata .
Lingua originaleEnglish
pagine (da-a)413-421
Numero di pagine9
RivistaMethods in Molecular Biology
Volume1508
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Antifungal drug resistance
  • Fungal pathogens
  • Gene sequencing
  • Genetics
  • Molecular Biology
  • Molecular analysis
  • Quantitative real-time RT-PCR

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