Molecular detection of resistance to azole components

Brunella Posteraro, Maurizio Sanguinetti, Antonietta Vella, Elena De Carolis

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance in both Candida and Aspergillus species may represent a useful means of monitoring the incidence of clinical isolates with antifungal resistance-associated gene alterations. Here, we describe molecular methods that have been developed to allow for accurate detection of azole-resistant isolates among C. glabrata and A. fumigatus fungal species.
Lingua originaleEnglish
pagine (da-a)423-435
Numero di pagine13
RivistaMethods in Molecular Biology
Volume1508
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Antifungal drug resistance
  • Fungal pathogens
  • Gene sequencing
  • Genetics
  • Molecular Biology
  • Molecular analysis
  • Quantitative real-time RT-PCR

Fingerprint

Entra nei temi di ricerca di 'Molecular detection of resistance to azole components'. Insieme formano una fingerprint unica.

Cita questo