Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection

Federico Costante, Leonardo Stella, Francesco Santopaolo, Antonio Gasbarrini, Maurizio Pompili, Tarik Asselah, Francesca Romana Ponziani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Hepatitis D virus (HDV) infection affects more than 10 million people worldwide, with an estimated prevalence of nearly 4.5% among HBsAg-positive individuals. Epidemiological studies have shown a significant increase in the prevalence of hepatocellular carcinoma (HCC) in patients with chronic HDV infection compared to those with chronic hepatitis B virus (HBV) monoinfection. Despite the clinical findings, data on molecular oncogenic mechanisms are limited and fragmentary. Moreover, the role of HDV in promoting the development of HCC has so far been controversial, because it is difficult to weigh the respective contributions of the two viruses. In this review, we focused on the direct oncogenic action of HDV, its role in modifying the tumor microenvironment, and the genetic signature of HDV-related HCC, comparing these features with HBV-related HCC.
Lingua originaleEnglish
pagine (da-a)713-724
Numero di pagine12
RivistaJOURNAL OF HEPATOCELLULAR CARCINOMA
Volume10
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • CDH
  • CHB
  • HCC
  • chronic delta hepatitis
  • chronic hepatitis B
  • dual infection
  • hepatitis B virus
  • hepatitis delta virus

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