Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis

Liverana Lauretti, Nicola Montano, Martina Offi, Ludovico Agostini, Luigi Maria Larocca, Roberto Pallini, Maurizio Martini, Tonia Cenci, Martina Giordano, Valerio M. Caccavella, Antonella Mangraviti, Olivi 1 Alessandro, Lucia Gabriele, and Quintino Giorgio D’Alessandris

Risultato della ricerca: Contributo in rivistaArticolo in rivista


The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine8
RivistaJournal of Personalized Medicine
Stato di pubblicazionePubblicato - 2022


  • VEGF
  • female
  • glioblastoma
  • trial population


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