Modulation of motor cortex neuronal networks by rTMS: comparison of local and remote effects of six different protocols of stimulation

Vincenzo Di Lazzaro, Fabio Pilato, Fioravante Capone, Federico Ranieri, Valerio Ricci, Pietro Bria, Riccardo Di Iorio, Chiara De Waure, Paolo Profice, M Dileone, G Musumeci, P Pasqualetti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

155 Citazioni (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) of human motor cortex can produce long-lasting changes in the excitability of excitatory and inhibitory neuronal networks. The effects of rTMS depend critically on stimulus frequency. The aim of our present study was to compare the effects of different rTMS protocols. We compared the aftereffects of 6 different rTMS protocols [paired associative stimulation at interstimulus intervals of 25 (PAS(25)) and 10 ms (PAS(10)); theta burst stimulation delivered as continuous (cTBS) or intermittent delivery pattern (iTBS); 1- and 5-Hz rTMS] on the excitability of stimulated and contralateral motor cortex in 10 healthy subjects. A pronounced increase of cortical excitability, evaluated by measuring the amplitude of motor evoked potentials (MEPs), was produced by iTBS (+56%) and PAS(25) (+45%). Five-hertz rTMS did not produce a significant increase of MEPs. A pronounced decrease of cortical excitability was produced by PAS(10) (-31%), cTBS (-29%), and 1-Hz rTMS (-20%). Short-interval intracortical inhibition was suppressed by PAS(10). Cortical silent period duration was increased by 1-Hz stimulation. No significant effect was observed in the contralateral hemisphere. Head-to-head comparison of the different protocols enabled us to identify the most effective paradigms for modulating the excitatory and inhibitory circuits activated by TMS.
Lingua originaleEnglish
pagine (da-a)2150-2156
Numero di pagine7
RivistaJournal of Neurophysiology
Volume105
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Adult
  • Evoked Potentials, Motor
  • Humans
  • Motor Cortex
  • Nerve Net
  • Neural Inhibition
  • Transcranial Magnetic Stimulation
  • Young Adult

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