Abstract
The recent development of compounds that induce cell differentiation in various
types of cancer cells has enabled the molecular mechanisms governing this kind of
induced cancer regression to be investigated. Moreover, this approach to
investigating the pathophysiology of neoplasia represents a promising
experimental model for proteomic analysis of cancer cells. Modulating neoplastic
cell differentiation grade may reveal cytodifferentiation-related protein
expression changes, and doing so in vitro has the advantage of less biological
variation. Hence, this analysis brings attention to molecular targets of the
so-called differentiating factors (i.e., retinoids, hybrid polar compounds,
tyrosine kinase inhibitors, etc.) as well as proteins that are frequently
associated with differentiation/dedifferentiation processes. The in vitro study
of these proteins and of their pathogenetic roles in cancer may ultimately result
in the discovery of cancer biomarkers with diagnostic, prognostic, and
therapeutic applications.
Lingua originale | English |
---|---|
pagine (da-a) | 229-237 |
Numero di pagine | 9 |
Rivista | PROTEOMICS. CLINICAL APPLICATIONS |
Stato di pubblicazione | Pubblicato - 2008 |
Keywords
- cancer
- cell differentiation
- proteomics
- stem cells