Modulation of alkaline phosphatase in different organs by ascorbic acid and related compounds

Alvaro Mordente, Elisabetta Meucci, Ga Miggiano, Ge Martorana, A. Castelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

The organ-specific modulation by ascorbic acid and related compounds on alkaline phosphatase activity of calf intestinal and human placental tissues has been studied at pH 8.0 and 37 degrees C. L(+)-ascorbic acid and its isomer D(-)-ascorbic acid inhibit to a similar extent the intestinal isoenzyme and appear to be more potent modifiers than dehydro-L-(+)-ascorbic acid. In contrast, the placental isoenzyme shows an initial activation by the three chemical agents, followed by an inhibition. The inhibition is lower with L(+)-ascorbic acid and D(-)-ascorbic acid, while its catalytic activity is affected only slightly by dehydro-L-(+)ascorbic acid.
Lingua originaleEnglish
pagine (da-a)219-224
Numero di pagine6
RivistaActa Vitaminologica et Enzymologica
Volume5
Stato di pubblicazionePubblicato - 1983

Keywords

  • Alkaline Phosphatase
  • Animals
  • Ascorbic Acid
  • Cattle
  • Dehydroascorbic Acid
  • Female
  • Humans
  • Intestines
  • Isoenzymes
  • Placenta
  • Pregnancy
  • Stereoisomerism
  • Time Factors

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