Abstract
The organ-specific modulation by ascorbic acid and related compounds on alkaline phosphatase activity of calf intestinal and human placental tissues has been studied at pH 8.0 and 37 degrees C. L(+)-ascorbic acid and its isomer D(-)-ascorbic acid inhibit to a similar extent the intestinal isoenzyme and appear to be more potent modifiers than dehydro-L-(+)-ascorbic acid. In contrast, the placental isoenzyme shows an initial activation by the three chemical agents, followed by an inhibition. The inhibition is lower with L(+)-ascorbic acid and D(-)-ascorbic acid, while its catalytic activity is affected only slightly by dehydro-L-(+)ascorbic acid.
Lingua originale | English |
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pagine (da-a) | 219-224 |
Numero di pagine | 6 |
Rivista | Acta Vitaminologica et Enzymologica |
Volume | 5 |
Stato di pubblicazione | Pubblicato - 1983 |
Keywords
- Alkaline Phosphatase
- Animals
- Ascorbic Acid
- Cattle
- Dehydroascorbic Acid
- Female
- Humans
- Intestines
- Isoenzymes
- Placenta
- Pregnancy
- Stereoisomerism
- Time Factors