Modulating risky decision-making in Parkinson's disease by transcranial direct current stimulation

Rosa Manenti, Maria Cotelli, A. Benussi, A. Alberici, V. Cantoni, R. Manenti, M. Brambilla, V. Dell'Era, S. Gazzina, M. Manes, V. Cristillo, A. Padovani, M. Cotelli, B. Borroni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Background and purpose: Performance on gambling tasks in Parkinson's disease (PD) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (DLPFC) in modulating gambling behaviour in PD. Methods: We assessed the effects of cathodal tDCS over the right DLPFC during the Iowa Gambling Task in 20 patients with PD, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal tDCS over the right DLPFC. Results: We observed that cathodal tDCS over the right DLPFC increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham tDCS. Conclusions: Cathodal tDCS over the right DLPFC possibly reduces the pathological overdrive in frontostriatal networks in patients with PD on dopaminergic medication, thus modulating impulsive and risky decision-making.
Lingua originaleEnglish
pagine (da-a)751-754
Numero di pagine4
RivistaEUROPEAN JOURNAL OF NEUROLOGY
Volume24
DOI
Stato di pubblicazionePubblicato - 2017
Pubblicato esternamente

Keywords

  • Parkinson's disease
  • dorsolateral prefrontal cortex
  • pathological gambling
  • transcranial direct current stimulation

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